Human mpox co-infection with advanced HIV-1 and XDR-TB in a MSM patient previously vaccinated against smallpox: A case report

IF 3.5 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Biosafety and Health Pub Date : 2024-06-01 DOI:10.1016/j.bsheal.2024.04.005
Yuan Fang , Fuchun Wang , Taiyi Jiang, Junyi Duan, Tao Huang, Hao Liu, Lin Jia, Han Jia, Benyong Yan, Mei Zhang, Wen Wang, Caiping Guo, Lifeng Liu, Yuening Zhang, Tong Zhang
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Abstract

Mpox is a zoonotic infectious disease caused by the mpox virus (MPXV). Historically, the majority of mpox cases have been documented in Central Africa. However, since May 2022, there has been a notable rise in reported cases from regions beyond Africa. Currently, over 110 countries spanning Europe, North America, South America, Asia, and other territories have reported mpox infections. This report details a case involving a patient who identifies as a man who has sex with men (MSM) and is concurrently infected with MPXV, human immunodeficiency virus type 1 (HIV-1), Pneumocystis jiroveci, as well as extensively drug-resistant tuberculosis (XDR-TB). This patient had also received a vaccination for smallpox in the past. Additionally, we provide photographic documentation charting the progression of dermatological manifestations associated with mpox. This case highlights the significance of sexual intercourse as a crucial mode of transmission for mpox. The rapid and widespread dissemination of the MPXV across various regions, especially among MSM communities, underscores the importance of enhancing preventive education efforts targeted at high-risk populations.

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一名曾接种过天花疫苗的 MSM 患者合并感染人类 mpox 与晚期 HIV-1 和 XDR-TB:病例报告
痘疹是一种由痘病毒(MPXV)引起的人畜共患传染病。从历史上看,大多数痘病病例都发生在中非。然而,自 2022 年 5 月以来,非洲以外地区报告的病例明显增多。目前,欧洲、北美、南美、亚洲和其他地区已有 110 多个国家报告了麻风痘感染病例。本报告详细介绍了一个病例,患者身份为男性同性性行为者 (MSM),同时感染了 MPXV、1 型人类免疫缺陷病毒 (HIV-1)、肺孢子菌 (Pneumocystis jiroveci),以及广泛耐药结核病 (XDR-TB)。这名患者过去还接种过天花疫苗。此外,我们还提供了照片资料,记录了与天花相关的皮肤病表现的发展过程。该病例强调了性交作为天花重要传播方式的重要性。MPXV 在各个地区,尤其是在男男性行为者群体中迅速而广泛地传播,凸显了加强针对高危人群的预防教育工作的重要性。
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来源期刊
Biosafety and Health
Biosafety and Health Medicine-Infectious Diseases
CiteScore
7.60
自引率
0.00%
发文量
116
审稿时长
66 days
期刊最新文献
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