The expression of immune co-stimulators as a prognostic predictor of head and neck squamous cell carcinomas and oral squamous cell carcinomas

IF 3.4 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of Dental Sciences Pub Date : 2024-07-01 DOI:10.1016/j.jds.2024.05.004
Shi-Rou Chang , Chung-Hsien Chou , Hsi-Feng Tu , Chung-Ji Liu , Kuo-Wei Chang , Shu-Chun Lin
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Abstract

Background/purpose

T cells require second immune checkpoint molecules for activation and immune memory after antigen presentation. We found that inducible co-stimulator (ICOS) has been a favorable prognostic factor amongst B7 immune checkpoint co-stimulators (ICSs) families in head and neck squamous cell carcinoma (HNSCC) and oral SCC (OSCC).

Materials and methods

This study analyzed the expression of non-B7 tumor necrosis factor (TNF) superfamily ICSs in the Cancer Genome Atlas (TCGA) HNSCC cohort, our OSCC cohort, and TCGA pan-cancer datasets. The correlation in expression, prognosis, and immune status was assessed.

Results

The higher expression of CD27, CD30, CD40L, death domain 3 (DR3), and OX40, presumably on the T cell surface, defined better overall survival of HNSCC patients. Besides, CD27, CD30, CD40L, and OX40 were highly correlated with ICOS expression in tumors. CD27, CD40L, and DR3 expression are higher in HPV+ HNSCC tumors than in HPV- tumors. The combined expression level of CD27/OX40 or CD27/CD40L/OX40 enables the potent survival prediction of small, less nodal involvement, early stage, and HPV + tumor subsets. Tumors expressing high CD27, CD30, CD40L, ICOS, and OX40 exhibited enhanced immune cell infiltration. The high correlation in the expression of these ICSs was also noted in the vast majority of tumor types in TCGA datasets.

Conclusion

The findings of this study not only confirm the potential of the concordant stimulation of CD27, CD30, CD40L, ICOS, and OX40 as a crucial strategy in cancer immunotherapy but also inspire further exploration into the field, highlighting the promising future of cancer treatment.

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免疫共刺激因子的表达作为头颈部鳞状细胞癌和口腔鳞状细胞癌的预后预测指标
背景/目的T细胞在抗原呈递后需要第二个免疫检查点分子来激活和免疫记忆。我们发现,在头颈部鳞状细胞癌(HNSCC)和口腔 SCC(OSCC)的 B7 免疫检查点辅助刺激因子(ICSs)家族中,诱导性辅助刺激因子(ICOS)是一个有利的预后因素。材料与方法 本研究分析了癌症基因组图谱(TCGA)HNSCC队列、我们的OSCC队列和TCGA泛癌症数据集中非B7肿瘤坏死因子(TNF)超家族ICSs的表达。结果CD27、CD30、CD40L、死亡结构域3(DR3)和OX40(可能在T细胞表面)的表达量越高,HNSCC患者的总生存率越高。此外,CD27、CD30、CD40L和OX40与肿瘤中ICOS的表达高度相关。CD27、CD40L和DR3在HPV+ HNSCC肿瘤中的表达高于HPV-肿瘤。CD27/OX40或CD27/CD40L/OX40的联合表达水平能有效预测小肿瘤、少结节累及肿瘤、早期肿瘤和HPV+肿瘤亚群的生存率。高表达 CD27、CD30、CD40L、ICOS 和 OX40 的肿瘤表现出更强的免疫细胞浸润。结论本研究的发现不仅证实了 CD27、CD30、CD40L、ICOS 和 OX40 的协同刺激作为癌症免疫疗法关键策略的潜力,而且还激发了对该领域的进一步探索,彰显了癌症治疗的美好前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Dental Sciences
Journal of Dental Sciences 医学-牙科与口腔外科
CiteScore
5.10
自引率
14.30%
发文量
348
审稿时长
6 days
期刊介绍: he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.
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