{"title":"The alteration of the relationship between cells and their context is the basis of a pathological condition","authors":"Domenico RIBATTI","doi":"10.1615/critreveukaryotgeneexpr.2024053711","DOIUrl":null,"url":null,"abstract":"Pathological conditions can be considered as alterations in the relationships between the cells of different tissues and organs and the microenvironment that surrounds them, primarily the different constituents of the extracellular matrix. The epithelial-mesenchymal transition is an example of how alterations in the relationships between epithelial cells can induce an alteration of their phenotypic characteristics and induce their migratory and invasive capacity.","PeriodicalId":56317,"journal":{"name":"Critical Reviews in Eukaryotic Gene Expression","volume":"57 1","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical Reviews in Eukaryotic Gene Expression","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1615/critreveukaryotgeneexpr.2024053711","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Pathological conditions can be considered as alterations in the relationships between the cells of different tissues and organs and the microenvironment that surrounds them, primarily the different constituents of the extracellular matrix. The epithelial-mesenchymal transition is an example of how alterations in the relationships between epithelial cells can induce an alteration of their phenotypic characteristics and induce their migratory and invasive capacity.
期刊介绍：
Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource.
Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered.
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