Identification of autoantibodies against PsoP27 in synovial fluid derived from psoriatic arthritis and rheumatoid arthritis patients.

IF 1.3 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2024-05-01 Epub Date: 2024-05-20 DOI:10.1080/00365513.2024.2352844
Marina Slobodkin, Ari Polachek, Victoria Furer, Ori Elkayam, Smadar Gertel
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Abstract

PsoP27 is an antigen expressed in psoriatic lesions. It plays an inflammatory role in psoriasis. This study objective was to characterize antibodies (Abs) against PsoP27 in patients with psoriatic arthritis (PsA) and rheumatoid arthritis (RA). Levels of Abs against native and citrullinated PsoP27 in PsA and RA patients' synovial fluid (SF) and sera were determined by ELISA. SF of osteoarthritis (OA) patients and sera of healthy donors were used as controls. Levels of Abs against PsoP27 were correlated with disease activity scores. Abs against native and citrullinated PsoP27 levels in SF of PsA (n = 48; 0.38 ± 0.03 and 0.44 ± 0.04, respectively) and RA (n = 22; 0.57 ± 0.1 and 0.62 ± 0.09, respectively) were significantly higher than in OA patients (n = 23; 0.14 ± 0.01 and 0.15 ± 0.01, respectively) (p < .0001). For both Abs, there were no significant differences between their level in PsA and RA patients. There was no difference in the level of Abs against citrullinated PsoP27 in SF of seronegative versus seropositive RA patients. Levels of Abs against both native and citrullinated PsoP27 in the SF and level of systemic C-reactive protein in PsA correlated positively, while in RA there were no significant correlations with disease activity scores. No differences in level of Abs against PsoP27 were found in the sera of all three study groups. Abs against native and citrullinated PsoP27 are present in PsA and RA SF but not in those of OA patients, suggesting a potential role of those Abs in inflammatory joint diseases.

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牛皮癣关节炎和类风湿性关节炎患者滑液中针对 PsoP27 的自身抗体的鉴定。
PsoP27 是一种在银屑病皮损中表达的抗原。它在银屑病中起着炎症作用。本研究旨在确定银屑病关节炎(PsA)和类风湿性关节炎(RA)患者体内针对 PsoP27 的抗体(Abs)的特征。研究采用 ELISA 方法测定了 PsA 和 RA 患者滑液(SF)和血清中针对原生和瓜氨酸化 PsoP27 的抗体水平。骨关节炎(OA)患者的滑液和健康供体的血清作为对照。针对 PsoP27 的抗体水平与疾病活动度评分相关。PsA(n = 48;分别为 0.38 ± 0.03 和 0.44 ± 0.04)和 RA(n = 22;分别为 0.57 ± 0.1 和 0.62 ± 0.09)患者 SF 中针对原生和瓜氨酸化 PsoP27 的 Abs 水平明显高于 OA 患者(n = 23;分别为 0.14 ± 0.01 和 0.15 ± 0.01)(p<0.05)。
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来源期刊
CiteScore
3.50
自引率
4.80%
发文量
85
审稿时长
4-8 weeks
期刊介绍: The Scandinavian Journal of Clinical and Laboratory Investigation is an international scientific journal covering clinically oriented biochemical and physiological research. Since the launch of the journal in 1949, it has been a forum for international laboratory medicine, closely related to, and edited by, The Scandinavian Society for Clinical Chemistry. The journal contains peer-reviewed articles, editorials, invited reviews, and short technical notes, as well as several supplements each year. Supplements consist of monographs, and symposium and congress reports covering subjects within clinical chemistry and clinical physiology.
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