Gowri Kalugotla , Vivien Marmerstein , Megan T Baldridge
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引用次数: 0
Abstract
Interferons (IFNs) are an integral component of the host innate immune response during viral infection. Recent advances in the study of type I and III IFNs suggest that though both types counteract viral infection, type III IFNs act predominantly at epithelial barrier sites, while type I IFNs drive systemic responses. The dynamics and specific roles of type I versus III IFNs have been studied in the context of infection by a variety of enteric pathogens, including reovirus, rotavirus, norovirus, astrovirus, and intestinal severe acute respiratory syndrome coronavirus 2, revealing shared patterns of regulatory influence. An important role for the gut microbiota, including the virome, in regulating homeostasis and priming of intestinal IFN responses has also recently emerged.
干扰素（IFNs）是病毒感染期间宿主先天免疫反应不可或缺的组成部分。对 I 型和 III 型 IFNs 研究的最新进展表明，虽然两种类型的 IFNs 都能抵御病毒感染，但 III 型 IFNs 主要作用于上皮屏障部位，而 I 型 IFNs 则驱动全身反应。在多种肠道病原体感染的背景下，对 I 型和 III 型 IFNs 的动态和特定作用进行了研究，这些病原体包括雷诺病毒、轮状病毒、诺如病毒、星状病毒和肠道严重急性呼吸综合征冠状病毒 2，揭示了共同的调控影响模式。最近还出现了肠道微生物群（包括病毒群）在调节肠道 IFN 反应的平衡和启动方面的重要作用。
期刊介绍：
Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed.
In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.
Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students.
Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.
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