Auditory Effects of Acoustic Noise From 3-T Brain MRI in Neonates With Hearing Protection

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-05-22 DOI:10.1002/jmri.29450

Chao Jin PhD, Huifang Zhao MM, Huan Li MM, Peiyao Chen MM, Cong Tian MM, PhD, Xianjun Li PhD, Miaomiao Wang MD, Congcong Liu MD, Qinli Sun MM, Jie Zheng MD, Baiya Li MD, Xihui Zhou MD, Richard Salvi PhD, Jian Yang PhD

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Abstract

Background

Neonates with immature auditory function (eg, weak/absent middle ear muscle reflex) could conceivably be vulnerable to noise-induced hearing loss; however, it is unclear if neonates show evidence of hearing loss following MRI acoustic noise exposure.

Purpose

To explore the auditory effects of MRI acoustic noise in neonates.

Study Type

Prospective.

Subjects

Two independent cohorts of neonates (N = 19 and N = 18; mean gestational-age, 38.75 ± 2.18 and 39.01 ± 1.83 weeks).

Field Strength/Sequence

T1-weighted three-dimensional gradient-echo sequence, T2-weighted fast spin-echo sequence, single-shot echo-planar imaging-based diffusion-tensor imaging, single-shot echo-planar imaging-based diffusion-kurtosis imaging and T2-weighted fluid-attenuated inversion recovery sequence at 3.0 T.

Assessment

All neonates wore ear protection during scan protocols lasted ~40 minutes. Equivalent sound pressure levels (SPLs) were measured for both cohorts. In cohort1, left- and right-ear auditory brainstem response (ABR) was measured before (baseline) and after (follow-up) MRI, included assessment of ABR threshold, wave I, III and V latencies and interpeak interval to determine the functional status of auditory nerve and brainstem. In cohort2, baseline and follow-up left- and right-ear distortion product otoacoustic emission (DPOAE) amplitudes were assessed at 1.2 to 7.0 kHz to determine cochlear function.

Statistical Test

Wilcoxon signed-rank or paired t-tests with Bonferroni's correction were used to compare the differences between baseline and follow-up ABR and DPOAE measures.

Results

Equivalent SPLs ranged from 103.5 to 113.6 dBA. No significant differences between baseline and follow-up were detected in left- or right-ear ABR measures (P > 0.999, Bonferroni corrected) in cohort1, or in DPOAE levels at 1.2 to 7.0 kHz in cohort2 (all P > 0.999 Bonferroni corrected except for left-ear levels at 3.5 and 7.0 kHz with corrected P = 0.138 and P = 0.533).

Data Conclusion

A single 40-minute 3-T MRI with equivalent SPLs of 103.5–113.6 dBA did not result in significant transient disruption of auditory function, as measured by ABR and DPOAE, in neonates with adequate hearing protection.

Evidence Level

Technical Efficacy

Stage 5.

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有听力保护的新生儿 3 T 脑磁共振成像的声噪听觉效应。

背景：新生儿的听觉功能尚未发育成熟（例如，中耳肌肉反射弱/不存在），可以想象他们很容易受到噪声引起的听力损失的影响；然而，新生儿在暴露于核磁共振声学噪声后是否会出现听力损失的证据尚不清楚。目的：探讨核磁共振声学噪声对新生儿听觉的影响：研究类型：前瞻性：两组独立的新生儿（N = 19 和 N = 18；平均胎龄为 38.75 ± 2.18 周和 39.01 ± 1.83 周）：场强/序列：T1加权三维梯度回波序列、T2加权快速自旋回波序列、基于单次回波平面成像的弥散张量成像、基于单次回波平面成像的弥散峰度成像和3.0 T的T2加权液体衰减反转恢复序列：所有新生儿在持续约 40 分钟的扫描过程中均佩戴护耳装置。对两组新生儿的等效声压级（SPL）进行了测量。在队列 1 中，在磁共振成像之前（基线）和之后（随访）测量了左耳和右耳听性脑干反应（ABR），包括评估 ABR 阈值、I 波、III 波和 V 波潜伏期以及峰间间隔，以确定听神经和脑干的功能状态。在队列2中，基线和随访左耳和右耳畸变产物耳声发射（DPOAE）振幅在1.2至7.0千赫进行评估，以确定耳蜗功能：采用Wilcoxon符号秩检验或配对t检验及Bonferroni校正来比较基线与随访ABR和DPOAE测量值之间的差异：等效声压级介于 103.5 到 113.6 dBA 之间。在队列 1 中，左耳或右耳 ABR 测量值（P > 0.999，Bonferroni 校正）和队列 2 中 1.2 至 7.0 kHz 的 DPOAE 水平（除左耳 3.5 和 7.0 kHz 水平的校正 P = 0.138 和 P = 0.533 外，Bonferroni 校正后的所有 P > 0.999）在基线和随访之间均未发现明显差异：证据等级：2.技术功效：技术功效：第 5 阶段。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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