Review: Progress towards research on the toxicology of pyrimethanil

IF 3.9 3区环境科学与生态学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Comparative Biochemistry and Physiology C-toxicology & Pharmacology Pub Date : 2024-05-21 DOI:10.1016/j.cbpc.2024.109940

Risi Chen , Tingting Liu , Dan Deng , Linzhe Huang , Meixin Min , Xiaoping Xiao

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Abstract

Pyrimethanil is a persistent environmental pollutant that poses a significant threat to human health. In this review, we summarize the fungicidal mechanism of pyrimethanil and its toxicological effects on aquatic organisms and mammals, as well as its impact on growth and development as an endocrine disruptor. Additionally, we investigate the metabolism of pyrimethanil in mammals and its molecular mechanism in the occurrence of Alzheimer's disease. Furthermore, this review outlines the influence of climate change on the toxicity of pyrimethanil, emphasizing the need to consider the impact of mixtures of multiple compounds on human health. Finally, we propose several promising future directions for pyrimethanil research, believing that there is a better understanding of the interaction between pyrimethanil and organisms, as well as the development of techniques to remove pyrimethanil, may be the best approach to eliminating the threat posed by this compound.

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回顾：嘧菌酯毒理学研究进展。

嘧菌酯是一种持久性环境污染物，对人类健康构成严重威胁。在这篇综述中，我们总结了嘧菌酯的杀菌机制及其对水生生物和哺乳动物的毒理影响，以及它作为内分泌干扰物对生长发育的影响。此外，我们还研究了嘧菌酯在哺乳动物体内的代谢及其导致阿尔茨海默病发生的分子机制。此外，本综述还概述了气候变化对嘧菌酯毒性的影响，强调需要考虑多种化合物混合物对人类健康的影响。最后，我们提出了嘧菌酯研究的几个前景看好的未来方向，认为更好地了解嘧菌酯与生物之间的相互作用以及开发去除嘧菌酯的技术，可能是消除这种化合物威胁的最佳方法。

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来源期刊

Comparative Biochemistry and Physiology C-toxicology & Pharmacology 医学-动物学

CiteScore

7.50

自引率

5.10%

发文量

206

审稿时长

30 days

期刊介绍： Part C: Toxicology and Pharmacology. This journal is concerned with chemical and drug action at different levels of organization, biotransformation of xenobiotics, mechanisms of toxicity, including reactive oxygen species and carcinogenesis, endocrine disruptors, natural products chemistry, and signal transduction with a molecular approach to these fields.