Pharmacogenomics in Lebanon: current status, challenges and opportunities

IF 2.9 3区 医学 Q2 GENETICS & HEREDITY Pharmacogenomics Journal Pub Date : 2024-05-22 DOI:10.1038/s41397-024-00336-z
Lorenzo Chidiac, Hady Yazbeck, Rami Mahfouz, Nathalie K. Zgheib
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Abstract

Pharmacogenomics (PGx) research and applications are of utmost relevance in Lebanon considering its population genetic diversity. Moreover, as a country with regional leadership in medicine and higher education, Lebanon holds a strong potential in contributing to PGx research and clinical implementation. In this manuscript, we first review and evaluate the available PGx research conducted in Lebanon, then describe the current status of PGx practice in Lebanon while reflecting on the local and regional challenges, and highlighting areas for action, and opportunities to move forward. We specifically expand on the status of PGx at the American University of Beirut Faculty of Medicine and Medical Center as a case study and guide for the further development of local and regional comprehensive PGx research, teaching, and clinical implementation programs. We also delve into the status of PGx knowledge and education, and prospects for further advancement such as with online courses and certificates.

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黎巴嫩的药物基因组学:现状、挑战和机遇。
考虑到黎巴嫩人口基因的多样性,药物基因组学(PGx)的研究和应用对该国具有极其重要的意义。此外,作为一个在医学和高等教育领域处于地区领先地位的国家,黎巴嫩在促进 PGx 研究和临床实施方面拥有强大的潜力。在本手稿中,我们首先回顾和评估了在黎巴嫩开展的现有 PGx 研究,然后描述了黎巴嫩 PGx 实践的现状,同时反思了当地和地区面临的挑战,并强调了需要采取行动的领域和前进的机遇。我们特别扩展了贝鲁特美国大学医学系和医疗中心的 PGx 现状,将其作为案例研究和进一步发展当地和地区综合 PGx 研究、教学和临床实施计划的指南。我们还深入探讨了 PGx 知识和教育的现状,以及在线课程和证书等进一步发展的前景。
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来源期刊
Pharmacogenomics Journal
Pharmacogenomics Journal 医学-药学
CiteScore
7.20
自引率
0.00%
发文量
35
审稿时长
6-12 weeks
期刊介绍: The Pharmacogenomics Journal is a print and electronic journal, which is dedicated to the rapid publication of original research on pharmacogenomics and its clinical applications. Key areas of coverage include: Personalized medicine Effects of genetic variability on drug toxicity and efficacy Identification and functional characterization of polymorphisms relevant to drug action Pharmacodynamic and pharmacokinetic variations and drug efficacy Integration of new developments in the genome project and proteomics into clinical medicine, pharmacology, and therapeutics Clinical applications of genomic science Identification of novel genomic targets for drug development Potential benefits of pharmacogenomics.
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