Effect of Alaska pollock-gelatin sheet on repair strength and regeneration of nerve.

The Journal of hand surgery, European volume Pub Date : 2025-01-01 Epub Date: 2024-05-23 DOI:10.1177/17531934241251670

Ryosuke Tsujisaka, Taku Suzuki, Shinsuke Shibata, Takuji Iwamoto, Tetsushi Taguchi, Masaya Nakamura

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Abstract

The aim of the study was to investigate the repair strength and the biocompatibility of Alaska pollock-derived gelatin (ApGltn) sheet for nerve repair. Cadaveric digital nerves were repaired with double suture, single suture + ApGltn sheet, single suture + fibrin glue, single suture, ApGltn sheet and fibrin. Maximum failure loads were measured (20 nerves each). Rat sciatic nerves were repaired with double suture, single suture + ApGltn sheet, single suture, ApGltn sheet, fibrin glue and resection (10 nerves each). Macroscopic appearance, muscle weight and histopathological findings were examined 8 weeks postoperatively. The mean failure load of ApGltn sheet (0.39 N) was significantly higher than that of a fibrin (0.05 N), and that of single suture + ApGltn sheet (1.32 N) was significantly higher than that of a single suture alone (0.97 N). Functional and histological assessments showed similar nerve recovery among the suture, ApGltn and fibrin groups. ApGltn sheet has potential for clinical application as an alternative to fibrin.

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阿拉斯加花粉-明胶薄片对神经修复强度和再生的影响

该研究旨在探讨阿拉斯加狭鳕源明胶（ApGltn）片用于神经修复的修复强度和生物相容性。用双线缝合、单线缝合+ApGltn薄片、单线缝合+纤维蛋白胶、单线缝合、ApGltn薄片和纤维蛋白修复尸体数字神经。测量了最大破坏载荷（各 20 根神经）。用双线缝合、单线缝合 + ApGltn 片、单线缝合、ApGltn 片、纤维蛋白胶和切除法修复大鼠坐骨神经（各 10 根神经）。术后 8 周检查宏观外观、肌肉重量和组织病理学结果。ApGltn薄片的平均失效负荷（0.39 N）明显高于纤维蛋白（0.05 N），而单线缝合+ApGltn薄片的失效负荷（1.32 N）明显高于单线缝合（0.97 N）。功能和组织学评估显示，缝合组、ApGltn 组和纤维蛋白组的神经恢复情况相似。作为纤维蛋白的替代品，ApGltn 片材具有临床应用潜力。

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The Journal of hand surgery, European volume

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