RDW Predicts Fibrosis in Patients with Chronic Hepatitis B Having Persistently Normal ALT Levels.

IF 1.5 Q3 HEALTH CARE SCIENCES & SERVICES Ethiopian Journal of Health Sciences Pub Date : 2023-07-01 DOI:10.4314/ejhs.v33i4.5
Basak Yilmaz Guller, Erdinc Gulumsek, Hilmi Erdem Sumbul, Begum Seyda Avci, Adnan Tas
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Abstract

Background: There are studies on the determination of hepatic fibrosis with noninvasive markers but data about liver biopsy results and noninvasive markers in patients with chronic hepatitis B (CHB) are limited. The aim of this study is to determine the relationship between pathological findings and noninvasive markers, and to determine the marker that predicts fibrosis in patients with consistently normal serum alanine aminotransferase (ALT) levels, diagnosed with CHB and undergoing liver biopsy.

Methods: A total of 122 patients with CHB, 29 of them with HbeAg (+), aged 30 years and older, HBV DNA > 2000 IU / ml, and serum ALT levels measured four times in the last year, were consistently normal, and 93 of them with HbeAg (-) were included in the study. Demographic characteristics of patients, laboratory parameters, histological activity index (HAI) and fibrosis values obtained in liver biopsy, and noninvasive markers (AP (age-platelet) index, APRI (AST/Platelet ratio) and FIB-4 score, neutrophil/lymphocyte ratio, mean platelet volume (MPV) and erythrocyte distribution width (RDW) were recorded.

Results: The relationship between RDW value and fibrosis was statistically significant in the HbeAg (+) group (p<0.001). The relationship between AP index, APRI and FIB-4 score, neutrophil/lymphocyte ratio and MPV with fibrosis was not statistically significant (>0.05 for each).

Conclusion: It has been shown that the RDW value can be used to predict fibrosis in CHB patients with normal ALT and HbeAg (+), and the cut-off value for RDW is 12.

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RDW 可预测 ALT 水平持续正常的慢性乙型肝炎患者的纤维化。
背景:有研究表明,非侵入性标志物可确定肝纤维化,但有关慢性乙型肝炎(CHB)患者肝活检结果和非侵入性标志物的数据却很有限。本研究旨在确定病理结果与无创标记物之间的关系,并确定在血清丙氨酸氨基转移酶(ALT)水平持续正常、确诊为慢性乙型肝炎并接受肝活检的患者中预测肝纤维化的标记物:研究共纳入122名CHB患者,其中29名患者HbeAg(+),年龄在30岁及以上,HBV DNA > 2000 IU / ml,且在过去一年中四次测量血清ALT水平均持续正常,93名患者HbeAg(-)。研究记录了患者的人口学特征、实验室参数、肝活检获得的组织学活性指数(HAI)和纤维化值,以及无创标记物(AP(年龄-血小板)指数、APRI(谷草转氨酶/血小板比率)和 FIB-4 评分、中性粒细胞/淋巴细胞比率、平均血小板体积(MPV)和红细胞分布宽度(RDW)):结果:在 HbeAg(+)组中,RDW 值与纤维化之间的关系具有统计学意义(P0.05):结论:研究表明,RDW值可用于预测ALT正常且HbeAg(+)的CHB患者的纤维化,RDW的临界值为12。
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来源期刊
Ethiopian Journal of Health Sciences
Ethiopian Journal of Health Sciences HEALTH CARE SCIENCES & SERVICES-
CiteScore
2.10
自引率
8.30%
发文量
137
审稿时长
12 weeks
期刊介绍: Ethiopian Journal of Health Sciences is a general health science journal addressing clinical medicine, public health and biomedical sciences. Rarely, it covers veterinary medicine
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