Epigenome-metabolism nexus in the retina: implications for aging and disease.

IF 13.6 2区生物学 Q1 GENETICS & HEREDITY Trends in Genetics Pub Date : 2024-08-01 Epub Date: 2024-05-22 DOI:10.1016/j.tig.2024.04.012

Anupam K Mondal, Mohita Gaur, Jayshree Advani, Anand Swaroop

引用次数: 0

Abstract

Intimate links between epigenome modifications and metabolites allude to a crucial role of cellular metabolism in transcriptional regulation. Retina, being a highly metabolic tissue, adapts by integrating inputs from genetic, epigenetic, and extracellular signals. Precise global epigenomic signatures guide development and homeostasis of the intricate retinal structure and function. Epigenomic and metabolic realignment are hallmarks of aging and highlight a link of the epigenome-metabolism nexus with aging-associated multifactorial traits affecting the retina, including age-related macular degeneration and glaucoma. Here, we focus on emerging principles of epigenomic and metabolic control of retinal gene regulation, with emphasis on their contribution to human disease. In addition, we discuss potential mitigation strategies involving lifestyle changes that target the epigenome-metabolome relationship for maintaining retinal function.

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视网膜的表观基因组-代谢关系：对衰老和疾病的影响。

表观基因组修饰与代谢物之间的密切联系暗示了细胞代谢在转录调控中的关键作用。视网膜是一个高代谢组织，它通过整合遗传、表观遗传和细胞外信号的输入来进行适应。精确的全球表观基因组特征指导着错综复杂的视网膜结构和功能的发育与平衡。表观基因组和新陈代谢的调整是衰老的标志，凸显了表观基因组-新陈代谢关系与影响视网膜的衰老相关多因素特征（包括老年性黄斑变性和青光眼）之间的联系。在此，我们将重点介绍视网膜基因调控的表观基因组和代谢控制的新原理，并强调它们对人类疾病的影响。此外，我们还讨论了针对表观基因组-代谢组关系改变生活方式以维持视网膜功能的潜在缓解策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Genetics 生物-遗传学

CiteScore

20.90

自引率

0.90%

发文量

160

审稿时长

6-12 weeks

期刊介绍： Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.

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