Fibroblast growth factor 21 (FGF21): diagnostic, prognostic and therapeutic aspects in heart failure. A review

A. M. Alieva, N. V. Teplova, E. V. Reznik, I. Baykova, Nyurzhanna Kh. Khadzhieva, Kira V. Voronkova, Irina V. Kovtiukh, R. Valiev, I. A. Kotikova, I. G. Nikitin
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Abstract

Chronic heart failure (CHF) is a global medical, social and economic problem. Currently, the search and study of new biomarkers that can provide early diagnosis of CHF, serve as a laboratory tool for assessing the effectiveness of treatment, or be used as prognostic markers and risk stratification criteria are ongoing. Scientists' interest is focused, in particular, on studying the role of fibroblast growth factor 21 (FGF21) in CHF. There is increasing evidence highlighting the value of FGF21 as a new marker for the diagnosis and assessment of prognosis in patients with CHF. The role of FGF21 in CHF is very interesting due to its cardioprotective aspects. Final confirmation of the diagnostic, prognostic and therapeutic roles of FGF21 will come from future studies.
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成纤维细胞生长因子 21 (FGF21):心力衰竭的诊断、预后和治疗。综述
慢性心力衰竭(CHF)是一个全球性的医疗、社会和经济问题。目前,人们正在寻找和研究新的生物标志物,以提供慢性心力衰竭的早期诊断,作为评估治疗效果的实验室工具,或用作预后标志物和风险分层标准。科学家们的兴趣尤其集中在研究成纤维细胞生长因子 21 (FGF21) 在慢性心力衰竭中的作用。越来越多的证据表明,FGF21 是诊断和评估慢性心力衰竭患者预后的新标志物。由于 FGF21 具有保护心脏的作用,因此它在慢性心力衰竭中的作用非常引人关注。未来的研究将最终确认 FGF21 在诊断、预后和治疗方面的作用。
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