Theta Phase Precession and the Dynamics of Spatiotemporal Asymmetry in Hippocampal Place Fields

Abstract

A consistently observed characteristic of hippocampal place fields is the shifting of the field's center of mass and the subsequent development of asymmetry. This is evidenced by the expansion of the place field in an asymmetric manner over repeated traversals, wherein a rat's initial entry into the field prompts a low firing rate that substantially increases as it exits. Our study delves deeper into these spatiotemporal asymmetries of place field spiking, specifically examining their relationship with theta oscillations and disentangling the effects from environmental factors. Analysis of neuronal data from a T-maze alternation task revealed a distinct non-uniform firing pattern of place cells. This pattern was markedly skewed in relation to the phases of theta cycles, indicating a phase precession effect. We found that as the rat navigates through the place field, there is a systematic advancement of spike timing, with action potentials tending to cluster in the early phases of theta during the exit phase of the field. Such temporal coordination of spikes suggests that the timing of neural activity within theta cycles is as integral as spatial location, influencing the dynamics of place field expansion and potentially affecting the hippocampal local field potential. This discovery underscores the role of theta phase precession in spatial encoding, proposing a novel temporal component that could underpin the cognitive map within the hippocampus. R01 MH126236 R01 AG055544. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.