Invasive lobular breast cancer: Focus on prevention, genetics, diagnosis, and treatment

IF 3 3区 医学 Q2 ONCOLOGY Seminars in oncology Pub Date : 2024-06-01 DOI:10.1053/j.seminoncol.2024.05.001
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Abstract

Invasive lobular cancer (ILC) is the most common of the breast cancer special types, accounting for up to 15% of all breast malignancies. The distinctive biological features of ILC include the loss of the cell adhesion molecule E-cadherin, which drives the tumor's peculiar discohesive growth pattern, with cells arranged in single file and dispersed throughout the stroma. Typically, such tumors originate in the lobules, are more commonly bilateral compared to invasive ductal cancer (IDC) and require a more accurate diagnostic examination through imaging. They are luminal in molecular subtype, and exhibit estrogen and progesterone receptor positivity and HER2 negativity, thus presenting a more unpredictable response to neoadjuvant therapies. There has been a significant increase in research focused on this distinctive breast cancer subtype, including studies on its pathology, its clinical and surgical management, and the high-resolution definition of its genomic profile, as well as the development of new therapeutic perspectives. This review will summarize the heterogeneous pattern of this unique disease, focusing on challenges in its comprehensive clinical management and on future insights and research objectives.

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浸润性小叶乳腺癌:关注预防、遗传、诊断和治疗
浸润性小叶癌(ILC)是乳腺癌特殊类型中最常见的一种,占所有乳腺恶性肿瘤的 15%。浸润性小叶癌的显著生物学特征包括细胞粘附分子 E-cadherin 的缺失,这促使肿瘤呈现出特殊的盘状生长模式,细胞排列成单列,分散在整个基质中。此类肿瘤通常起源于乳腺小叶,与浸润性乳腺导管癌(IDC)相比更常见于双侧,需要通过影像学进行更准确的诊断检查。它们在分子亚型上属于管腔癌,表现为雌激素和孕激素受体阳性和 HER2 阴性,因此对新辅助疗法的反应更难预测。针对这一独特乳腺癌亚型的研究大幅增加,包括对其病理学、临床和手术治疗、基因组特征的高分辨率定义以及新疗法前景的开发。本综述将总结这种独特疾病的异质性模式,重点关注其综合临床管理方面的挑战以及未来的见解和研究目标。
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来源期刊
Seminars in oncology
Seminars in oncology 医学-肿瘤学
CiteScore
6.60
自引率
0.00%
发文量
58
审稿时长
104 days
期刊介绍: Seminars in Oncology brings you current, authoritative, and practical reviews of developments in the etiology, diagnosis and management of cancer. Each issue examines topics of clinical importance, with an emphasis on providing both the basic knowledge needed to better understand a topic as well as evidence-based opinions from leaders in the field. Seminars in Oncology also seeks to be a venue for sharing a diversity of opinions including those that might be considered "outside the box". We welcome a healthy and respectful exchange of opinions and urge you to approach us with your insights as well as suggestions of topics that you deem worthy of coverage. By helping the reader understand the basic biology and the therapy of cancer as they learn the nuances from experts, all in a journal that encourages the exchange of ideas we aim to help move the treatment of cancer forward.
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