Prevalence of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Individuals With Dystrophinopathy at a Tertiary Care Center in Chicago

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY Pediatric neurology Pub Date : 2024-05-19 DOI:10.1016/j.pediatrneurol.2024.05.011

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Abstract

Objective

To study the prevalence of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in individuals with dystrophinopathy compared with the general population.

Methods

Retrospective chart review to examine the prevalence of ADHD and ASD, diagnosed both formally and informally, in individuals with dystrophinopathy receiving care in the multidisciplinary neuromuscular clinic at the Ann and Robert H. Lurie Children's Hospital of Chicago.

Results

Our results demonstrate an ADHD prevalence of 18.40% and ASD prevalence of 12.73%, both significantly higher than those reported for the general population. Our results revealed a significant association between ADHD diagnosis and a positive family history but did not show a statistically significant association between prevalence of ADHD and the use of steroids.

Conclusion

Based on our current study results, we plan to further evaluate the prevalence, in a prospective cross-sectional manner, using validated screens for both ADHD and ASD.

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芝加哥一家三级医疗中心肌营养不良症患者中注意缺陷多动障碍和自闭症谱系障碍的患病率

研究肌营养不良患者中注意力缺陷/多动障碍（ADHD）和自闭症谱系障碍（ASD）的患病率，并与普通人群进行比较。方法通过回顾性病历审查，检查在安-罗伯特-卢瑞儿童医院多学科神经肌肉诊所接受治疗的肌营养不良患者中经正式和非正式诊断的注意力缺陷/多动障碍（ADHD）和自闭症谱系障碍（ASD）的患病率。结果我们的研究结果表明，ADHD 的患病率为 18.40%，ASD 的患病率为 12.73%，均显著高于普通人群的患病率。我们的研究结果表明，多动症诊断与阳性家族史之间存在显著关联，但多动症患病率与类固醇的使用之间并不存在统计学意义上的显著关联。结论根据我们目前的研究结果，我们计划采用前瞻性的横断面方式，使用经过验证的多动症和ASD筛查方法进一步评估患病率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric neurology 医学-临床神经学

CiteScore

4.80

自引率

2.60%

发文量

176

审稿时长

78 days

期刊介绍： Pediatric Neurology publishes timely peer-reviewed clinical and research articles covering all aspects of the developing nervous system. Pediatric Neurology features up-to-the-minute publication of the latest advances in the diagnosis, management, and treatment of pediatric neurologic disorders. The journal''s editor, E. Steve Roach, in conjunction with the team of Associate Editors, heads an internationally recognized editorial board, ensuring the most authoritative and extensive coverage of the field. Among the topics covered are: epilepsy, mitochondrial diseases, congenital malformations, chromosomopathies, peripheral neuropathies, perinatal and childhood stroke, cerebral palsy, as well as other diseases affecting the developing nervous system.