Clinical importance of anti-Ro52 antibody in polymyositis and dermatomyositis.

IF 1.8 4区医学 Q3 RHEUMATOLOGY Modern Rheumatology Pub Date : 2024-12-25 DOI:10.1093/mr/roae052

Toshiki Sugita, Hiroto Tsuboi, Naoki Sugita, Rai Akiyoshi, Yuki Kuroda, Akira Kawashima, Fumina Kawashima, Daiki Tabuchi, Fumika Honda, Ayako Ohyama, Saori Abe, Ayako Kitada, Hiromitsu Asashima, Haruka Miki, Shinya Hagiwara, Yuya Kondo, Isao Matsumoto

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Abstract

Objectives: To clarify the clinical features of anti-Ro52 antibody (Ab)-positive polymyositis (PM)/dermatomyositis (DM).

Methods: We retrospectively examined the clinical features and status of anti-Ro52 Abs in patients with PM/DM admitted to the University of Tsukuba Hospital between January 2019 and February 2023. We compared the anti-Ro52 Ab-positive and anti-Ro52 Ab-negative groups.

Results: A total of 40 patients were selected and analysed. Twenty-three cases were PM, and 17 cases were DM (including six clinically amyopathic DM). Twenty-two cases were positive for anti-Ro52 Ab, 14 for anti-ARS Ab, and 6 for anti-MDA5 Ab. Interstitial lung disease was detected in 29 cases, nine of which were rapidly progressive. Glucocorticoid-resistant cardiomyopathy was detected in six cases. Of the 22 anti-Ro52 Ab-positive cases, only 3 were single-positive and the remaining 19 cases simultaneously had other autoantibodies. Comparing the anti-Ro52 Ab-positive and anti-Ro52 Ab-negative groups, the frequencies of anti-ARS Ab positivity (63.6% vs. 0%), interstitial lung disease (95.5% vs. 44.4%), glucocorticoid-resistant cardiomyopathy (27.3% vs. 0%), concomitant use of immunosuppressants (95.5% vs. 55.6%), and levels of C-reactive protein were significantly higher in the anti-Ro52 Ab-positive group (P < .05).

Conclusions: Anti-Ro52 Abs were frequently positive in PM/DM, and may be useful as a severity marker.

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抗 Ro52 抗体对多发性肌炎和皮肌炎的临床意义。

目的明确抗Ro52抗体（Ab）阳性多发性肌炎（PM）/皮肌炎（DM）的临床特征：我们回顾性研究了2019年1月至2023年2月期间筑波大学附属医院收治的PM/DM患者的临床特征和抗Ro52抗体状态。我们比较了抗 Ro52 Ab 阳性组和阴性组：共选取了 40 名患者进行分析。诊断时的中位年龄为 61.5（48.8-69.3）岁，34 例为女性。23例为PM，17例为DM（包括6例临床淀粉样变性皮肌炎：CADM）。22例抗Ro52抗体阳性，14例抗ARS抗体阳性，6例抗MDA5抗体阳性。29例患者出现间质性肺病（ILD），其中9例病情进展迅速。6例检测出糖皮质激素（GC）抵抗性心肌病，3例检测出恶性肿瘤，4例检测出Sjögren综合征（SS）。在 22 例抗 Ro52 Ab 阳性病例中，只有 3 例为单一阳性，其余 19 例同时存在其他自身抗体。对比抗Ro52抗体阳性组和阴性组，抗Ro52抗体阳性组的抗ARS抗体阳性率（63.6% vs. 0%）、ILD（95.5% vs. 44.4%）、GC抵抗性心肌病（27.3% vs. 0%）、同时使用免疫抑制剂（95.5% vs. 55.6%）和C反应蛋白（CRP）水平均显著高于抗Ro52抗体阳性组（p结论：PM/DM 患者的抗 Ro52 Ab 常呈阳性，抗 Ro52 Ab 阳性患者的抗ARS Ab 阳性率、ILD、GC-抵抗性心肌病、同时使用免疫抑制剂和 CRP 水平明显更高。抗Ro52抗体可作为 PM/DM 的严重程度标记物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Modern Rheumatology RHEUMATOLOGY-

CiteScore

4.90

自引率

9.10%

发文量

146

审稿时长

1.5 months

期刊介绍： Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery. Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered. Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions