Static and dynamic guided bone regeneration using a shape-memory polyethylene terephthalate membrane: An experimental study in rabbit mandible

IF 3.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Clinical Implant Dentistry and Related Research Pub Date : 2024-05-28 DOI:10.1111/cid.13337

Kazuhiro Imoto, Karen Hoshi, Kenji Odashima, Shinnosuke Nogami, Hidero Unuma, Kensuke Yamauchi

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Abstract

Background

Periosteal expansion (PEO) results in the formation of new bone in the space created between existing bone by expanding the periosteum. PEO has already been performed on rabbit parietal bone and effective new bone formation has been demonstrated. In this study, the utility of a polyethylene terephthalate (PET) membrane as an activator was evaluated in the more complex morphology of the mandible.

Methods

A PET membrane coated with hydroxyapatite (HA)/gelatine was placed in the rabbit mandibular bone at lower margin of mandibular molar region underneath periosteum, and screw-fixed. In the experimental group, the membrane was bent and screw-fixed along the lateral surface of the bone, with removal of the outer screw after 7 days followed by activation of the membrane. The experimental group was divided into two subgroups: with and without a waiting period for activation. Three animals were euthanized at 3 weeks and another three at 5 weeks postoperatively. Bone formation was assessed using micro-CT as well as histomorphometric and histological methods.

Results

No PET membrane-related complications were observed. The area of newly formed bone and the percentage of new bone in the space created by the stretched periosteum did not significantly differ between the control and experimental groups. However, in the experimental group a greater volume was present after 5 weeks than after 3 weeks. Histologically, bone formation occurred close to the site of cortical bone perforation, with many sinusoidal vessels extending through the perforations in the new bone into the overlying fibrous tissue. Inflammatory cells were not seen in the bone.

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使用形状记忆聚对苯二甲酸乙二醇酯膜进行静态和动态引导骨再生：兔下颌骨实验研究。

背景：骨膜扩张术（PEO）通过扩张骨膜，在现有骨骼之间形成新的骨骼。已在兔顶骨上进行了 PEO 试验，并证明能有效形成新骨。本研究评估了聚对苯二甲酸乙二醇酯（PET）膜作为激活剂在形态更为复杂的下颌骨中的效用：方法：将涂有羟基磷灰石（HA）/明胶的 PET 膜置于兔下颌骨，位于下颌磨牙区下缘骨膜下方，并用螺钉固定。在实验组中，将骨膜弯曲并沿骨的外侧表面用螺钉固定，7 天后取下外侧螺钉，然后激活骨膜。实验组分为两个亚组：有等待激活期和无等待激活期。三只动物在术后 3 周安乐死，另外三只在术后 5 周安乐死。使用显微 CT 以及组织形态学和组织学方法对骨形成进行评估：结果：未观察到 PET 膜相关并发症。对照组和实验组新形成骨的面积以及拉伸骨膜形成的空间中新骨的百分比没有显著差异。不过，实验组在 5 周后出现的骨量大于 3 周后。从组织学角度看，骨形成发生在皮质骨穿孔部位附近，许多窦状血管通过新骨穿孔延伸到上覆的纤维组织中。骨中未见炎性细胞。

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来源期刊

Clinical Implant Dentistry and Related Research 医学-牙科与口腔外科

CiteScore

6.00

自引率

13.90%

发文量

103

审稿时长

4-8 weeks

期刊介绍： The goal of Clinical Implant Dentistry and Related Research is to advance the scientific and technical aspects relating to dental implants and related scientific subjects. Dissemination of new and evolving information related to dental implants and the related science is the primary goal of our journal. The range of topics covered by the journals will include but be not limited to: New scientific developments relating to bone Implant surfaces and their relationship to the surrounding tissues Computer aided implant designs Computer aided prosthetic designs Immediate implant loading Immediate implant placement Materials relating to bone induction and conduction New surgical methods relating to implant placement New materials and methods relating to implant restorations Methods for determining implant stability A primary focus of the journal is publication of evidenced based articles evaluating to new dental implants, techniques and multicenter studies evaluating these treatments. In addition basic science research relating to wound healing and osseointegration will be an important focus for the journal.