Gene transfer agents: structural and functional properties of domesticated viruses.

IF 14 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Microbiology Pub Date : 2024-05-27 DOI:10.1016/j.tim.2024.05.002
Matthew W Craske, Jason S Wilson, Paul C M Fogg
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Abstract

Horizontal exchange of DNA between bacteria and archaea is prevalent and has major potential implications for genome evolution, plasticity, and population fitness. Several transfer mechanisms have been identified, including gene transfer agents (GTAs). GTAs are intricately regulated domesticated viruses that package host DNA into virus-like capsids and transfer this DNA throughout the bacterial community. Several important advances have recently been made in our understanding of these unusual particles. In this review, we highlight some of these findings, primarily for the model GTA produced by Rhodobacter capsulatus but also for newly identified GTA producers. We provide key insights into these important genetic elements, including the differences between GTAs from their ancestral bacteriophages, their regulation and control, and their elusive evolutionary function.

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基因转移剂:驯化病毒的结构和功能特性。
细菌和古细菌之间的 DNA 水平交换非常普遍,对基因组进化、可塑性和种群适宜性具有重大潜在影响。目前已发现几种转移机制,包括基因转移剂(GTAs)。基因转移剂是一种调控复杂的驯化病毒,它将宿主 DNA 包装成病毒样的外壳,并在整个细菌群落中转移这种 DNA。最近,我们在了解这些不同寻常的颗粒方面取得了一些重要进展。在这篇综述中,我们将重点介绍其中的一些发现,主要是针对荚膜罗杆菌产生的模式 GTA,以及新发现的 GTA 生产者。我们提供了对这些重要遗传因子的关键见解,包括 GTA 与其祖先噬菌体之间的差异、它们的调节和控制以及它们难以捉摸的进化功能。
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来源期刊
Trends in Microbiology
Trends in Microbiology 生物-生化与分子生物学
CiteScore
25.30
自引率
0.60%
发文量
193
审稿时长
6-12 weeks
期刊介绍: Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.
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