NCPbook: A comprehensive database of noncanonical peptides.

IF 6.5 1区生物学 Q1 PLANT SCIENCES Plant Physiology Pub Date : 2024-09-02 DOI:10.1093/plphys/kiae311

Abdul Sami, Mengjia Fu, Haoqiang Yin, Usman Ali, Lei Tian, Shunxi Wang, Jinghua Zhang, Xueyan Chen, Hehuan Li, Minghui Chen, Wen Yao, Liuji Wu

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Abstract

Noncanonical peptides (NCPs) are a class of peptides generated from regions previously thought of as noncoding, such as introns, 5' UTRs, 3' UTRs, and intergenic regions. In recent years, the significance and diverse functions of NCPs have come to light, yet a systematic and comprehensive NCP database remains absent. Here, we developed NCPbook (https://ncp.wiki/ncpbook/), a database of evidence-supported NCPs, which aims to provide a resource for efficient exploration, analysis, and manipulation of NCPs. NCPbook incorporates data from diverse public databases and scientific literature. The current version of NCPbook includes 180,676 NCPs across 29 different species, evidenced by MS, ribosome profiling, or molecular experiments. These NCPs are distributed across kingdoms, comprising 123,408 from 14 plant species, 56,999 from 7 animal species, and 269 from 8 microbial species. Furthermore, NCPbook encompasses 9,166 functionally characterized NCPs playing important roles in immunity, stress resistance, growth, and development. Equipped with a user-friendly interface, NCPbook allows users to search, browse, visualize, and retrieve data, making it an indispensable platform for researching NCPs in various plant, animal, and microbial species.

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NCPbook：非典型肽综合数据库。

非典多肽（NCPs）是一类从以前被认为是非编码区域（如内含子、5' 非翻译区（UTRs）、3' UTRs 和基因间区域）生成的多肽。近年来，NCPs 的重要性和多样化功能逐渐被人们所认识，但系统而全面的 NCP 数据库仍然缺失。在此，我们开发了 NCPbook (https://ncp.wiki/ncpbook/)，这是一个有证据支持的 NCPs 数据库，旨在为有效探索、分析和操作 NCPs 提供资源。NCPbook 整合了来自不同公共数据库和科学文献的数据。当前版本的 NCPbook 包括 29 个不同物种的 180,676 个 NCPs，这些 NCPs 由质谱分析（MS）、核糖体分析（Ribo-seq）或分子实验（ME）证明。这些 NCPs 分布在不同领域，其中 123,408 个来自 14 个植物物种，56,999 个来自 7 个动物物种，269 个来自 8 个微生物物种。此外，NCPbook 还收录了 9,166 个在免疫、抗压、生长和发育中发挥重要作用的功能表征 NCP。NCPbook 配备了友好的用户界面，允许用户搜索、浏览、可视化和检索数据，是研究各种植物、动物和微生物物种中 NCPs 不可或缺的平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plant Physiology 生物-植物科学

CiteScore

12.20

自引率

5.40%

发文量

535

审稿时长

2.3 months

期刊介绍： Plant Physiology® is a distinguished and highly respected journal with a rich history dating back to its establishment in 1926. It stands as a leading international publication in the field of plant biology, covering a comprehensive range of topics from the molecular and structural aspects of plant life to systems biology and ecophysiology. Recognized as the most highly cited journal in plant sciences, Plant Physiology® is a testament to its commitment to excellence and the dissemination of groundbreaking research. As the official publication of the American Society of Plant Biologists, Plant Physiology® upholds rigorous peer-review standards, ensuring that the scientific community receives the highest quality research. The journal releases 12 issues annually, providing a steady stream of new findings and insights to its readership.