{"title":"A new acetophenone derivative from Rhododendron irroratum subsp. pogonostylum","authors":"Yong-Fu Lu, Si-Xuan Liu, Chun-Lin Guo, Si-Yang Dai, Yi-Hui Yang, Chang Li, Yue-Hu Pei","doi":"10.1016/j.phytol.2024.05.005","DOIUrl":null,"url":null,"abstract":"<div><p>One previously undescribed acetophenone derivative, named as rhodoirroratin (<strong>1</strong>), was isolated from <em>Rhododendron irroratum</em> subsp. <em>pogonostylum</em> along with four known compounds (<strong>2–5</strong>), which were isolated from the genus for the first time. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of compound <strong>1</strong> was assigned by the calculated NMR analysis. Compounds <strong>1</strong>–<strong>3</strong> had effects on LPS-induced NO release in RAW264.7 cells.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 275-279"},"PeriodicalIF":1.3000,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390024000776","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
One previously undescribed acetophenone derivative, named as rhodoirroratin (1), was isolated from Rhododendron irroratum subsp. pogonostylum along with four known compounds (2–5), which were isolated from the genus for the first time. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of compound 1 was assigned by the calculated NMR analysis. Compounds 1–3 had effects on LPS-induced NO release in RAW264.7 cells.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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