RADICALS-HD sheds light on the role of ADT addition to post-operative radiotherapy

IF 81.1 1区 医学 Q1 ONCOLOGY Nature Reviews Clinical Oncology Pub Date : 2024-05-30 DOI:10.1038/s41571-024-00912-z
Diana Romero
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RADICALS-HD揭示了在术后放疗中添加ADT的作用
中危或高危局部前列腺癌患者的标准治疗方法是在前期放疗的基础上加用短程雄激素剥夺疗法(ADT);然而,ADT在根治性前列腺切除术后接受放疗的患者中的作用尚不明确。在这项试验中,符合在前列腺癌根治术后任何时间接受放疗条件的患者被随机分配(1:1:1)接受单纯放疗或ADT(LHRH激动剂或比卡鲁胺)治疗,疗程分别为6个月或24个月(短疗程或长疗程)。鼓励参与试验的研究机构对患者进行三向分配,但也允许进行双向分配以促进招募。2010 年,该试验重新进行了两次比较,均以无转移生存期(MFS)为主要终点。中位随访时间为 9 年。
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来源期刊
CiteScore
99.40
自引率
0.40%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.
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