Association between renal α-klotho and renal pathology among patients with chronic kidney disease.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Pub Date : 2024-10-01 Epub Date: 2024-05-31 DOI:10.1111/1744-9987.14165

Yan Guo, Feng Wan, Yan-Peng Shi, Hong-Mei Zhang, Ru-Chun Yang

{"title":"Association between renal α-klotho and renal pathology among patients with chronic kidney disease.","authors":"Yan Guo, Feng Wan, Yan-Peng Shi, Hong-Mei Zhang, Ru-Chun Yang","doi":"10.1111/1744-9987.14165","DOIUrl":null,"url":null,"abstract":"Introduction: This study was designed to investigate whether renal α-klotho levels are associated with renal pathology. This is the first report on patients with chronic kidney disease (CKD).Methods: We conducted a retrospective observational study. A total of 65 CKD patients were enrolled. Serum and renal biopsy samples were collected. Estimated glomerular filtration rate (eGFR) was examined by biochemical test. And α-klotho expressions were assessed by RT-PCR and immunohistochemistry. In addition, detailed microscopic findings were reviewed.Results: Renal α-klotho levels are associated positively with eGFR, and negatively with renal pathology, including interstitial fibrosis, inflammatory cell infiltration, and tubular atrophy.Conclusions: The renal α-klotho is related to renal pathology.","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"769-774"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/1744-9987.14165","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/31 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: This study was designed to investigate whether renal α-klotho levels are associated with renal pathology. This is the first report on patients with chronic kidney disease (CKD).

Methods: We conducted a retrospective observational study. A total of 65 CKD patients were enrolled. Serum and renal biopsy samples were collected. Estimated glomerular filtration rate (eGFR) was examined by biochemical test. And α-klotho expressions were assessed by RT-PCR and immunohistochemistry. In addition, detailed microscopic findings were reviewed.

Results: Renal α-klotho levels are associated positively with eGFR, and negatively with renal pathology, including interstitial fibrosis, inflammatory cell infiltration, and tubular atrophy.

Conclusions: The renal α-klotho is related to renal pathology.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

慢性肾脏病患者肾脏α-克洛托与肾脏病理之间的关系。

简介本研究旨在探讨肾脏α-克洛托水平是否与肾脏病理相关。这是第一份关于慢性肾脏病（CKD）患者的报告：我们进行了一项回顾性观察研究。方法：我们进行了一项回顾性观察研究，共招募了 65 名 CKD 患者。收集了血清和肾活检样本。通过生化检验检测估计肾小球滤过率（eGFR）。并通过 RT-PCR 和免疫组化评估了 α-klotho 的表达。此外，还回顾了详细的显微镜检查结果：结果：肾脏α-klotho水平与eGFR呈正相关，与肾脏病理变化（包括肾间质纤维化、炎症细胞浸润和肾小管萎缩）呈负相关：结论：肾脏α-klotho与肾脏病理相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

自引率

0.00%

发文量