Optical coherence tomography for the screening of anterior chamber inflammation in paediatric patients diagnosed with juvenile idiopathic arthritis.

IF 3.4 4区医学 Q2 RHEUMATOLOGY Clinical and experimental rheumatology Pub Date : 2024-07-01 Epub Date: 2024-05-21 DOI:10.55563/clinexprheumatol/t7pn4v

Cristina Del-Prado-Sánchez, Ana Llorca-Cardeñosa, Begoña Yeste-Mayoral, Stefano Grixolli-Mazzon, María Fernanda Barros-Centeno, Jesús Díaz-Cascajosa, Jordi Antón, Joan Calzada-Hernández, Juan Manuel Mosquera, Sonia Carriqui, Andrea Zacarías, Marta Morales-Ballús

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Abstract

Objectives: To evaluate the effectiveness of the anterior segment optical coherence tomography (AS-OCT) for the screening of anterior uveitis in children diagnosed with juvenile idiopathic arthritis (JIA).

Methods: A cross-sectional, observational, non-randomised study was conducted in JIA patients younger than 18 years. All patients underwent anterior segment (AS-OCT) and macular OCT.

Results: A total of 300 eyes of 150 patients diagnosed with JIA were included; 74% were females, and mean age was 11.12 ± 3.51 years old (range 4.13-18.60). In the slit-lamp examination, anterior uveitis was diagnosed in 16 eyes. In the AS-OCT, anterior uveitis was suspected in 27 eyes; cells were detected in 27 eyes and retrokeratic precipitates in 5 eyes. Sensitivity was 0.94 and specificity was 0.96, positive predictive value was 0.59 and negative predictive value was 0.99, and Kappa-Cohen index was 0.71.

Conclusions: AS-OCT could be considered for the screening of anterior segment uveitis in children diagnosed with JIA.

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光学相干断层扫描用于筛查确诊为幼年特发性关节炎的儿科患者的前房炎症。

目的评估前段光学相干断层扫描（AS-OCT）在筛查幼年特发性关节炎（JIA）患儿前葡萄膜炎方面的有效性：方法：在18岁以下的JIA患者中开展了一项横断面、观察性、非随机研究。所有患者均接受了前段（AS-OCT）和黄斑OCT检查：共纳入了 150 名确诊为 JIA 患者的 300 只眼睛，其中 74% 为女性，平均年龄为 11.12 ± 3.51 岁（范围为 4.13-18.60 岁）。在裂隙灯检查中，16 只眼睛被诊断为前葡萄膜炎。在 AS-OCT 中，27 只眼睛怀疑患有前葡萄膜炎；27 只眼睛检测到细胞，5 只眼睛检测到角膜后沉淀物。灵敏度为 0.94，特异度为 0.96，阳性预测值为 0.59，阴性预测值为 0.99，Kappa-Cohen 指数为 0.71：AS-OCT可用于筛查确诊为JIA的儿童前节葡萄膜炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and experimental rheumatology 医学-风湿病学

CiteScore

6.10

自引率

18.90%

发文量

377

审稿时长

3-6 weeks

期刊介绍： Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.