Methotrexate for the neurologist.

IF 2.4 Q2 CLINICAL NEUROLOGY PRACTICAL NEUROLOGY Pub Date : 2024-09-13 DOI:10.1136/pn-2024-004156

Aaron Jesuthasan, Aravindhan Baheerathan, Stephen Auger, Rachel Dorsey, Robina Coker, Nowlan Selvapatt, Stuart Viegas

引用次数: 0

Abstract

The use of methotrexate in clinical practice has expanded significantly in recent years, as an effective chemotherapeutic agent as well as disease-modifying treatment for conditions such as rheumatoid arthritis, psoriasis and Crohn's disease. It is also used as a steroid-sparing agent for a range of inflammatory diseases of the central and peripheral nervous systems. Clinical neurologists must, therefore, know how to start and uptitrate methotrexate, its monitoring requirements and its potential toxicities. This review aims first to explore the evidence base for using methotrexate in various neurological diseases and second to discuss important practicalities around its use, ensuring its safe application and appropriate monitoring.

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给神经科医生的甲氨蝶呤

近年来，甲氨蝶呤作为一种有效的化疗药物以及类风湿性关节炎、银屑病和克罗恩病等疾病的改变病情治疗药物，在临床实践中的应用已大大扩展。此外，它还被用作中枢神经系统和外周神经系统一系列炎症疾病的类固醇备用药。因此，临床神经科医生必须了解如何开始和加大甲氨蝶呤的剂量、其监测要求和潜在毒性。本综述的目的首先是探讨在各种神经系统疾病中使用甲氨蝶呤的证据基础，其次是讨论有关甲氨蝶呤使用的重要实际问题，确保其安全应用和适当监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PRACTICAL NEUROLOGY Medicine-Neurology (clinical)

CiteScore

3.70

自引率

3.60%

发文量

113

期刊介绍： The essential point of Practical Neurology is that it is practical in the sense of being useful for everyone who sees neurological patients and who wants to keep up to date, and safe, in managing them. In other words this is a journal for jobbing neurologists - which most of us are for at least part of our time - who plough through the tension headaches and funny turns week in and week out. Primary research literature potentially relevant to routine clinical practice is far too much for any neurologist to read, let alone understand, critically appraise and assimilate. Therefore, if research is to influence clinical practice appropriately and quickly it has to be digested and provided to neurologists in an informative and convenient way.

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