Exploring novel protein-based biomarkers for advancing breast cancer diagnosis: A review

IF 2.5 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY Clinical biochemistry Pub Date : 2024-05-31 DOI:10.1016/j.clinbiochem.2024.110776

Christina Jane Vellan , Tania Islam , Sumadee De Silva , Nur Aishah Mohd Taib , Galhena Prasanna , Jaime Jacqueline Jayapalan

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Abstract

This review provides a contemporary examination of the evolving landscape of breast cancer (BC) diagnosis, focusing on the pivotal role of novel protein-based biomarkers. The overview begins by elucidating the multifaceted nature of BC, exploring its prevalence, subtypes, and clinical complexities. A critical emphasis is placed on the transformative impact of proteomics, dissecting the proteome to unravel the molecular intricacies of BC.

Navigating through various sources of samples crucial for biomarker investigations, the review underscores the significance of robust sample processing methods and their validation in ensuring reliable outcomes. The central theme of the review revolves around the identification and evaluation of novel protein-based biomarkers. Cutting-edge discoveries are summarised, shedding light on emerging biomarkers poised for clinical application.

Nevertheless, the review candidly addresses the challenges inherent in biomarker discovery, including issues of standardisation, reproducibility, and the complex heterogeneity of BC. The future direction section envisions innovative strategies and technologies to overcome existing challenges. In conclusion, the review summarises the current state of BC biomarker research, offering insights into the intricacies of proteomic investigations.

As precision medicine gains momentum, the integration of novel protein-based biomarkers emerges as a promising avenue for enhancing the accuracy and efficacy of BC diagnosis. This review serves as a compass for researchers and clinicians navigating the evolving landscape of BC biomarker discovery, guiding them toward transformative advancements in diagnostic precision and personalised patient care.

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探索基于蛋白质的新型生物标记物，促进乳腺癌诊断：综述。

本综述对不断发展的乳腺癌（BC）诊断方法进行了当代研究，重点关注基于蛋白质的新型生物标记物的关键作用。综述首先阐明了乳腺癌的多面性，探讨了其发病率、亚型和临床复杂性。重点强调了蛋白质组学的变革性影响，通过剖析蛋白质组来揭示 BC 分子的复杂性。综述介绍了对生物标记物研究至关重要的各种样本来源，强调了稳健的样本处理方法及其验证对确保可靠结果的重要意义。综述的中心主题围绕新型蛋白质生物标记物的鉴定和评估展开。综述总结了前沿发现，揭示了有望应用于临床的新兴生物标记物。不过，综述坦率地探讨了生物标记物发现过程中固有的挑战，包括标准化、可重复性以及 BC 复杂的异质性等问题。未来方向部分提出了克服现有挑战的创新战略和技术。总之，该综述总结了BC生物标志物研究的现状，对错综复杂的蛋白质组学研究提出了见解。随着精准医学的发展，整合基于蛋白质的新型生物标志物成为提高 BC 诊断准确性和有效性的一条大有可为的途径。这篇综述是研究人员和临床医生在不断变化的 BC 生物标志物发现领域中的指南针，将引导他们实现诊断精确性和个性化患者护理方面的变革性进步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical biochemistry 医学-医学实验技术

CiteScore

5.10

自引率

0.00%

发文量

151

审稿时长

25 days

期刊介绍： Clinical Biochemistry publishes articles relating to clinical chemistry, molecular biology and genetics, therapeutic drug monitoring and toxicology, laboratory immunology and laboratory medicine in general, with the focus on analytical and clinical investigation of laboratory tests in humans used for diagnosis, prognosis, treatment and therapy, and monitoring of disease.