Factors associated with sexual dysfunction in patients with bipolar disorder.

IF 1.2 4区医学 Q4 NEUROSCIENCES Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique Pub Date : 2024-05-31 DOI:10.1016/j.encep.2024.03.008

Mona Lagha, Wided Homri, Naouel Dhaouadi, Sarra Rouached

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Abstract

Objectives: The aims of our study were to assess the sexual function in men with bipolar disorder type 1 in remission and to determine the various sociodemographic, clinical and therapeutic factors associated with sexual dysfunction.

Methods: We conducted a cross-sectional study over an 18-month period (January 2020-June 2021) in which we included men followed up for bipolar disorder type 1 in the euthymic phase strictly defined by a score <8 on the Young Mania Rating Scale and a score ≤7 on the Hamilton Depression Rating Scale. Sexual function was assessed using the Arizona Sexual Experiences Scale (Asex) in its Arabic-validated version.

Results: Sixty patients were included in the study. The mean age was 42.5 (SD=11.1) years. Among the patients, 68% had sexual dysfunction according to the total score of the Asex scale. According to univariate analysis, several factors were significantly associated with sexual dysfunction in patients with bipolar disorder type 1: age (P=0.001), total number of hospitalizations for thymic relapse (P=0.015), total number of depressive episodes (P=0.006) and depressive dominant polarity (P=0.046). The factors identified as modifying sexuality according to the total score of the Asex scale by multivariate analysis were age at first antipsychotic prescription: P=0.01; ORa=1.109; 95% CI [1.021-1.206] and number of hospitalizations for thymic relapse: P=0.015; ORa=1.259; 95% CI [1.046-1.546].

Conclusion: Studies assessing factors associated with sexual dysfunction in patients with bipolar disorder type 1 in euthymia were mostly concerned with the effects of psychotropic drugs on sexual function, with factors inherent in bipolar illness itself not widely addressed in the literature. According to the results of our study, sexual dysfunction in patients with bipolar disorder in the euthymic phase is frequent and significantly associated with clinical factors inherent in the bipolar illness itself and its course.

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躁郁症患者性功能障碍的相关因素。

研究目的我们的研究旨在评估缓解期1型双相情感障碍男性患者的性功能，并确定与性功能障碍相关的各种社会人口、临床和治疗因素：方法：我们进行了一项为期 18 个月（2020 年 1 月至 2021 年 6 月）的横断面研究，研究对象包括躁狂症 1 型的男性患者，他们处于缓解期，严格按照评分标准定义：研究共纳入 60 名患者。平均年龄为 42.5 (SD=11.1) 岁。根据无性量表的总分，68%的患者有性功能障碍。根据单变量分析，有几个因素与双相情感障碍 1 型患者的性功能障碍显著相关：年龄（P=0.001）、胸腺复发住院总次数（P=0.015）、抑郁发作总次数（P=0.006）和抑郁主导极性（P=0.046）。通过多变量分析，根据无性量表的总分，被确定为改变性情的因素有：首次开具抗精神病药物处方的年龄：P=0.01；ORa=1.109；95% CI [1.021-1.206]；胸腺疾病复发住院次数：P=0.015；ORa=1.259；95% CI [1.046-1.546]：结论：对处于健康状态的1型双相情感障碍患者的性功能障碍相关因素进行评估的研究大多关注精神药物对性功能的影响，而双相情感障碍疾病本身的固有因素在文献中并未得到广泛关注。根据我们的研究结果，处于痊愈期的双相情感障碍患者经常出现性功能障碍，而且与双相情感障碍疾病本身及其病程中固有的临床因素有很大关系。

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来源期刊

Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique 医学-精神病学

CiteScore

4.60

自引率

7.40%

发文量

162

审稿时长

6-12 weeks

期刊介绍： Une revue française de renommée internationale. - Un comite de rédaction représentant tous les aspects de la prise en charge psychiatrique du patient. - Une sélection rigoureuse d''articles faisant l''objet de plusieurs expertises. - Des travaux d''auteurs et de chercheurs de renommée internationale. - Des indexations dans les grandes bases de données (Current Contents, Excerpta Medica, etc.). - Un facteur d''impact qui témoigne de la grande notoriété de la revue. La tribune des publications originales de haut niveau. - Une très grande diversité des sujets traités, rigoureusement sélectionnés à travers des sommaires dynamiques : - des éditoriaux de médecins référents, - une revue de presse sur les actualités internationales, - des articles originaux pour approfondir vos connaissances, - des mises au point et des cas cliniques pour engager votre réflexion sur les indications et choix possibles au travers de mises en situation clinique, - des dossiers thématiques pour faire le tour d''une question. - L''actualité de l''AFPB : L''Encéphale publie régulièrement des comptes rendus de l''Association française de psychiatrie clinique.