Recent progress in stimuli-responsive polymeric micelles for targeted delivery of functional nanoparticles

IF 15.9 1区化学 Q1 CHEMISTRY, PHYSICAL Advances in Colloid and Interface Science Pub Date : 2024-05-29 DOI:10.1016/j.cis.2024.103206

Zhonglin Cao , Xiaoling Zuo , Xiaochen Liu , Gaixia Xu , Ken-Tye Yong

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Abstract

Stimuli-responsive polymeric micelles have emerged as a revolutionary approach for enhancing the in vivo stability, biocompatibility, and targeted delivery of functional nanoparticles (FNPs) in biomedicine. This article comprehensively reviews the preparation methods of these polymer micelles, detailing the innovative strategies employed to introduce stimulus responsiveness and surface modifications essential for precise targeting. We delve into the breakthroughs in utilizing these micelles to selectively deliver various FNPs including magnetic nanoparticles, upconversion nanoparticles, gold nanoparticles, and quantum dots, highlighting their transformative impact in the biomedical realm. Concluding, we present an insight into the current research landscape, addressing the challenges at hand, and envisioning the future trajectory in this burgeoning domain. Join us as we navigate the exciting confluence of polymer science and nanotechnology in reshaping biomedical solutions.

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用于定向输送功能纳米粒子的刺激响应型聚合物胶束的最新进展。

刺激响应型聚合物胶束已成为一种革命性的方法，可增强生物医学中功能纳米粒子（FNPs）的体内稳定性、生物相容性和靶向递送。本文全面回顾了这些聚合物胶束的制备方法，详细介绍了为引入刺激响应性和精确靶向所必需的表面修饰而采用的创新策略。我们深入探讨了利用这些胶束选择性递送各种 FNPs（包括磁性纳米粒子、上转换纳米粒子、金纳米粒子和量子点）的突破性进展，强调了它们在生物医学领域的变革性影响。最后，我们将深入探讨当前的研究状况，应对当前的挑战，并展望这一新兴领域的未来发展轨迹。请加入我们的行列，与我们一起探索聚合物科学与纳米技术在重塑生物医学解决方案方面令人兴奋的交汇点。

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来源期刊

Advances in Colloid and Interface Science 化学-物理化学

CiteScore

28.50

自引率

2.60%

发文量

175

审稿时长

31 days

期刊介绍： "Advances in Colloid and Interface Science" is an international journal that focuses on experimental and theoretical developments in interfacial and colloidal phenomena. The journal covers a wide range of disciplines including biology, chemistry, physics, and technology. The journal accepts review articles on any topic within the scope of colloid and interface science. These articles should provide an in-depth analysis of the subject matter, offering a critical review of the current state of the field. The author's informed opinion on the topic should also be included. The manuscript should compare and contrast ideas found in the reviewed literature and address the limitations of these ideas. Typically, the articles published in this journal are written by recognized experts in the field.