Protective roles of some natural and synthetic aromatase inhibitors in testicular insufficiency caused by Bisphenol A exposure.

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES International Journal of Environmental Health Research Pub Date : 2025-02-01 Epub Date: 2024-06-02 DOI:10.1080/09603123.2024.2362810

Mehmet Berköz, Serap Yalın, Ömer Türkmen

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Abstract

In our study, the protective role of synthetic aromatase inhibitors anastrozole (ANS), letrozole (LTZ) and exemestane (EXM) and natural aromatase inhibitors resveratrol (RSV) and apigenin (APG) against testicular failure caused by exposure to Bisphenol A (BPA) was investigated. The epididymal sperm concentration, sperm motility and sperm morphology were determined. Oxidative stress and inflammatory response parameters were examined and histological examinations were performed in testicular tissues. Our results revealed that BPA exposure decreased serum testosterone and estrogen levels, increased FSH and LH levels (p < 0.05). BPA has been found to increase oxidative stress and inflammatory response and disrupt the histological structure. Also, BPA exposure decreased testicular weight, epididymal sperm concentration and motility, and increased abnormal sperm rate (p < 0.05). These results show that ANS, LTZ and RSV treatments reduce the BPA-induced testicular damage.

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一些天然和合成芳香化酶抑制剂在双酚 A 暴露导致的睾丸功能不全中的保护作用。

我们的研究调查了合成芳香化酶抑制剂阿那曲唑（ANS）、来曲唑（LTZ）和依西美坦（EXM）以及天然芳香化酶抑制剂白藜芦醇（RSV）和芹菜素（APG）对暴露于双酚 A（BPA）引起的睾丸功能衰竭的保护作用。研究测定了附睾精子浓度、精子活力和精子形态。对氧化应激和炎症反应参数进行了检测，并对睾丸组织进行了组织学检查。结果表明，暴露于双酚 A 会降低血清睾酮和雌激素水平，增加 FSH 和 LH 水平（P P

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来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.