Moderating effects of PER3 gene DNA methylation on the association between problematic mobile phone use and chronotype among Chinese young adults: Focus on gender differences.

IF 6.6 1区 医学 Q1 PSYCHIATRY Journal of Behavioral Addictions Pub Date : 2024-06-03 Print Date: 2024-06-26 DOI:10.1556/2006.2024.00027
Tingting Li, Yuming Chen, Yang Xie, Shuman Tao, Liwei Zou, Yajuan Yang, Fangbiao Tao, Xiaoyan Wu
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Abstract

Objective: To investigate the rates of problematic mobile phone use (PMPU) and chronotypes in young adults, and examine the associations of PMPU with chronotypes, as well as its gender differences. Furthermore, we explored the moderating role of PER3 gene DNA methylation on the associations.

Methods: From April to May 2019, a total of 1,179 young adults were selected from 2 universities in Anhui and Jiangxi provinces. The Self-rating Questionnaire for Adolescent Problematic Mobile Phone Use (SQAPMPU) and reduced Morningness-Eveningness Questionnaire (rMEQ) were adopted to investigate PMPU and chronotypes in young adults, respectively. Moreover, 744 blood samples were collected to measure PER3 gene DNA methylation. Multivariate logistic regression models were established to analyze the associations between PMPU and chronotypes. Moderating analysis was used to determine whether PER3 gene DNA methylation moderated the relationships between PMPU and chronotypes.

Results: The prevalence of PMPU, morning chronotypes (M-types), neutral chronotypes (N-types), and evening chronotypes (E-types) of young adults were 24.6%, 18.4%, 71.1%, and 10.5%, respectively. Multivariate logistic regression results indicated that PMPU was positively correlated with E-types (OR = 3.53, 95%CI: 2.08-6.00), and the association was observed only in females after stratified by gender (OR = 5.36, 95%CI: 2.70-10.67). Furthermore, PER3 gene DNA methylation has a negative moderating role between PMPU and chronotypes and has a sex-based difference.

Conclusions: This study can provide valuable information for the prevention and control of circadian rhythm disturbance among young adults from the perspective of epidemiology and biological etiology.

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PER3基因DNA甲基化对中国青少年使用问题手机与慢性型之间关系的调节作用:关注性别差异
目的调查青壮年中问题手机使用率(PMPU)和时间型,研究PMPU与时间型的关联及其性别差异。此外,我们还探讨了PER3基因DNA甲基化对两者关联的调节作用:2019年4月至5月,我们从安徽和江西两省的2所高校共选取了1179名青壮年。采用青少年问题性手机使用自评量表(SQAPMPU)和还原型晨醒-活力问卷(rMEQ)分别调查青壮年的PMPU和时型。此外,研究人员还采集了 744 份血液样本,以测定 PER3 基因的 DNA 甲基化情况。研究人员建立了多变量逻辑回归模型来分析 PMPU 与时间型之间的关系。调节分析用于确定 PER3 基因 DNA 甲基化是否调节了 PMPU 与时型之间的关系:结果:PMPU、早晨时型(M 型)、中性时型(N 型)和傍晚时型(E 型)在年轻人中的流行率分别为 24.6%、18.4%、71.1% 和 10.5%。多变量逻辑回归结果表明,PMPU 与 E 型呈正相关(OR = 3.53,95%CI:2.08-6.00),按性别分层后,仅在女性中观察到这种关联(OR = 5.36,95%CI:2.70-10.67)。此外,PER3基因的DNA甲基化在PMPU和时间型之间具有负向调节作用,且存在性别差异:本研究可从流行病学和生物病因学的角度为预防和控制青壮年昼夜节律紊乱提供有价值的信息。
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来源期刊
CiteScore
12.30
自引率
7.70%
发文量
91
审稿时长
20 weeks
期刊介绍: The aim of Journal of Behavioral Addictions is to create a forum for the scientific information exchange with regard to behavioral addictions. The journal is a broad focused interdisciplinary one that publishes manuscripts on different approaches of non-substance addictions, research reports focusing on the addictive patterns of various behaviors, especially disorders of the impulsive-compulsive spectrum, and also publishes reviews in these topics. Coverage ranges from genetic and neurobiological research through psychological and clinical psychiatric approaches to epidemiological, sociological and anthropological aspects.
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