The potential emerging role of piRNA/PIWI complex in virus infection.

IF 1.9 4区医学 Q3 GENETICS & HEREDITY Virus Genes Pub Date : 2024-08-01 Epub Date: 2024-06-04 DOI:10.1007/s11262-024-02078-3

Yanyan Li, Kai Wang, Wen Liu, Yan Zhang

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Abstract

P-element-induced wimpy testis-interacting RNAs (piRNAs), a class of small noncoding RNAs with about 24-32 nucleotides, often interact with PIWI proteins to form a piRNA/PIWI complex that could influence spermiogenesis, transposon silencing, epigenetic regulation, etc. PIWI proteins have a highly conserved function in a variety of species and are usually expressed in germ cells. However, increasing evidence has revealed the important role of the piRNA/PIWI complex in the occurrence and prognosis of various human diseases and suggests its potential application in the diagnosis and treatment of related diseases, becoming a prominent marker for these human diseases. Recent studies have confirmed that piRNA/PIWI complexes or piRNAs are abnormally expressed in some viral infections, effecting disease progression and viral replication. In this study, we reviewed the association between the piRNA/PIWI complex and several human disease-associated viruses, including human papillomavirus, human immunodeficiency virus, human rhinovirus, severe acute respiratory syndrome coronavirus 2, respiratory syncytial virus, and herpes simplex virus type 1.

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piRNA/PIWI 复合物在病毒感染中的潜在作用。

P-元素诱导的睾丸干扰RNA（piRNA）是一类约有24-32个核苷酸的小型非编码RNA，常与PIWI蛋白相互作用，形成piRNA/PIWI复合物，可影响精子发生、转座子沉默、表观遗传调控等。PIWI 蛋白在多种物种中具有高度保守的功能，通常在生殖细胞中表达。然而，越来越多的证据揭示了 piRNA/PIWI 复合物在人类各种疾病的发生和预后中的重要作用，并表明其有可能应用于相关疾病的诊断和治疗，成为这些人类疾病的一个重要标志物。最近的研究证实，piRNA/PIWI 复合物或 piRNA 在一些病毒感染中异常表达，影响疾病的进展和病毒的复制。在本研究中，我们回顾了 piRNA/PIWI 复合物与几种人类疾病相关病毒之间的关联，包括人类乳头瘤病毒、人类免疫缺陷病毒、人类鼻病毒、严重急性呼吸系统综合征冠状病毒 2、呼吸道合胞病毒和单纯疱疹病毒 1 型。

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来源期刊

Virus Genes 医学-病毒学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Viruses are convenient models for the elucidation of life processes. The study of viruses is again on the cutting edge of biological sciences: systems biology, genomics, proteomics, metagenomics, using the newest most powerful tools. Huge amounts of new details on virus interactions with the cell, other pathogens and the hosts – animal (including human), insect, fungal, plant, bacterial, and archaeal - and their role in infection and disease are forthcoming in perplexing details requiring analysis and comments. Virus Genes is dedicated to the publication of studies on the structure and function of viruses and their genes, the molecular and systems interactions with the host and all applications derived thereof, providing a forum for the analysis of data and discussion of its implications, and the development of new hypotheses.