Endogenous androgens, coronary atheroma and remodeling in women with suspected ischemic heart disease: A report from the Women's Ischemia Syndrome Evaluation (WISE) study

IF 1.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS American heart journal plus : cardiology research and practice Pub Date : 2024-05-31 DOI:10.1016/j.ahjo.2024.100411

Sachini Ranasinghe , Ankur Jain , Yasmeen Taha , Eileen Handberg , B. Delia Johnson , Vera Bittner , George Sopko , Carl J. Pepine , R. David Anderson , C. Noel Bairey Merz

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Abstract

Background

Women have smaller coronary size than men independent of body surface area. Female to male heart transplantation demonstrates coronary lumen enlargement.

Purpose

To investigate relationships between endogenous androgens and coronary luminal size in women with suspected ischemic heart disease (IHD).

Methods

We analyzed 69 women with available androgen levels.

Results

Group mean age was 54 ± 10 years with 64 % post-menopausal. Lumen cross-sectional area (CSA) and external elastic membrane (EEM) CSA positively correlated with free testosterone (FT) (r = 0.29, p = 0.049; r = 0.29, p = 0.01), respectively, and negatively correlated with SHBG (r = −0.26, p = 0.03; r = −0.29, p = 0.02), respectively. Atheroma CSA positively correlated with FT (r = 0.24. p = 0.05). These correlations became non-significant after adjusting for waist circumference.

Conclusions

In women with suspected ischemic heart disease, endogenous androgens, coronary atheroma and luminal size are related, and may be moderated by waist circumference.

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疑似缺血性心脏病女性的内源性雄激素、冠状动脉粥样斑块和重塑：妇女缺血综合征评估（WISE）研究报告

背景女性的冠状动脉尺寸小于男性，与体表面积无关。目的研究疑似缺血性心脏病（IHD）女性患者的内源性雄激素与冠状动脉管腔大小之间的关系。方法我们分析了 69 名雄激素水平可用的女性患者。结果组内平均年龄为 54 ± 10 岁，64%绝经后。管腔横截面积（CSA）和外部弹性膜（EEM）CSA分别与游离睾酮（FT）呈正相关（r = 0.29，p = 0.049；r = 0.29，p = 0.01），与SHBG呈负相关（r = -0.26，p = 0.03；r = -0.29，p = 0.02）。动脉瘤 CSA 与 FT 呈正相关（r = 0.24，p = 0.05）。结论在疑似缺血性心脏病女性中，内源性雄激素、冠状动脉粥样斑块和管腔大小相关，并可能受腰围的影响。

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