Alcogel formation analysis: An important step for scCO2 aerogel production

IF 3.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL Journal of Supercritical Fluids Pub Date : 2024-05-29 DOI:10.1016/j.supflu.2024.106321

Cristiana S.A. Bento, Beatriz Agostinho, Alberto Teixeira, Marco S. Reis, Hermínio C. de Sousa, Mara E.M. Braga

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Abstract

The production of biopolymeric aerogels, for tissue engineering, currently involves three steps: gelation (hydrogel), solvent exchange (alcogel), and supercritical drying (aerogel). The alcogel formation, the longest step, can be optimised by exploring high pressures/mild temperatures. This work aimed to integrate/optimise the production process of alginate/gelatine aerogels, by performing solvent exchange and drying continuously within the same equipment. High-pressure solvent exchange (HPSE) was compared with the conventional method by analysing the alcogel and solvent with two complementary analytical techniques: Differential Scanning Calorimetry (DSC) and Refractive Index (RI). HPSE resulted in a faster solvent exchange, reducing 86 % of the processing time. The solvent exchange conditions did not significantly affect the aerogel structure, density, porosity, and surface area. Still, HPSE and the drying time influenced pore distribution and decreased mechanical properties. The drying stage was optimised to 2 h, showing the feasibility of integrating solvent exchange and supercritical drying for alginate-gelatine aerogels production.

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气凝胶形成分析：生产二氧化碳气凝胶的重要步骤

用于组织工程的生物聚合物气凝胶的生产目前包括三个步骤：凝胶化（水凝胶）、溶剂交换（炼金凝胶）和超临界干燥（气凝胶）。炼金凝胶的形成是最长的步骤，可以通过探索高压/低温来优化。这项工作旨在整合/优化海藻酸/明胶气凝胶的生产过程，在同一设备中连续进行溶剂交换和干燥。通过使用两种互补的分析技术分析气凝胶和溶剂，对高压溶剂交换（HPSE）与传统方法进行了比较：差示扫描量热法（DSC）和折射率（RI）。HPSE 加快了溶剂交换速度，缩短了 86% 的加工时间。溶剂交换条件对气凝胶的结构、密度、孔隙率和表面积没有明显影响。不过，HPSE 和干燥时间会影响孔隙分布并降低机械性能。干燥阶段优化为 2 小时，这表明将溶剂交换和超临界干燥结合起来生产海藻酸明胶气凝胶是可行的。

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来源期刊

Journal of Supercritical Fluids 工程技术-工程：化工

CiteScore

7.60

自引率

10.30%

发文量

236

审稿时长

56 days

期刊介绍： The Journal of Supercritical Fluids is an international journal devoted to the fundamental and applied aspects of supercritical fluids and processes. Its aim is to provide a focused platform for academic and industrial researchers to report their findings and to have ready access to the advances in this rapidly growing field. Its coverage is multidisciplinary and includes both basic and applied topics. Thermodynamics and phase equilibria, reaction kinetics and rate processes, thermal and transport properties, and all topics related to processing such as separations (extraction, fractionation, purification, chromatography) nucleation and impregnation are within the scope. Accounts of specific engineering applications such as those encountered in food, fuel, natural products, minerals, pharmaceuticals and polymer industries are included. Topics related to high pressure equipment design, analytical techniques, sensors, and process control methodologies are also within the scope of the journal.