The significance of small noncoding RNAs in the pathogenesis of cardiovascular diseases

IF 6.9 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Genes & Diseases Pub Date : 2024-05-30 DOI:10.1016/j.gendis.2024.101342

Hemanyun Bai, Fanji Meng, Kangling Ke, Lingyan Fang, Weize Xu, Haitao Huang, Xiao Liang, Weiyan Li, Fengya Zeng, Can Chen

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Abstract

With the advancement of high-throughput sequencing and bioinformatics, an increasing number of overlooked small noncoding RNAs (sncRNAs) have emerged. These sncRNAs predominantly comprise transfer RNA-derived fragments (tsRNAs), PIWI-interacting RNAs (piRNAs), Ro-associated non-coding RNAs (RNYs or Y-RNAs), small nucleolar RNAs (snoRNAs), and small nuclear RNAs (snRNAs). Each of these RNA types possesses distinct biological properties and plays specific roles in both physiological and pathological processes. The differential expression of sncRNAs substantially affects the occurrence and progression of various systemic diseases. However, their roles in the cardiovascular system remain unclear. Therefore, understanding the functionality and mechanisms of sncRNAs in the cardiovascular system holds promise for identifying novel targets and strategies for the diagnosis, prevention, and treatment of cardiovascular diseases. This review examines the biological characteristics of sncRNAs and their potential roles in cardiovascular diseases.

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小非编码 RNA 在心血管疾病发病机制中的意义

随着高通量测序和生物信息学的发展，出现了越来越多被忽视的小非编码 RNA（sncRNA）。这些 sncRNA 主要包括转运 RNA 衍生片段（tsRNA）、PIWI 交互 RNA（piRNA）、Ro 相关非编码 RNA（RNY 或 Y-RNA）、小核 RNA（snoRNA）和小核 RNA（snRNA）。这些 RNA 类型都具有不同的生物学特性，并在生理和病理过程中发挥特定的作用。sncRNAs 的不同表达对各种全身性疾病的发生和发展有重大影响。然而，它们在心血管系统中的作用仍不清楚。因此，了解 sncRNAs 在心血管系统中的功能和机制有望为诊断、预防和治疗心血管疾病找到新的靶点和策略。本综述探讨了 sncRNAs 的生物学特性及其在心血管疾病中的潜在作用。

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来源期刊

Genes & Diseases Multiple-

CiteScore

7.30

自引率

0.00%

发文量

347

审稿时长

49 days

期刊介绍： Genes & Diseases is an international journal for molecular and translational medicine. The journal primarily focuses on publishing investigations on the molecular bases and experimental therapeutics of human diseases. Publication formats include full length research article, review article, short communication, correspondence, perspectives, commentary, views on news, and research watch. Aims and Scopes Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis will be placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.