Zebrafish Xenographs in Oncology and Personalized Medicine

IF 1.5 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Biology Pub Date : 2024-06-05 DOI:10.1134/s0026893324700031
N. A. Lunina, D. R. Safina, S. V. Kostrov
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Abstract

The bony fish Danio rerio (zebrafish) has become one of the important vertebrate model organisms in biomedical cancer research and is used, among other things, for the development of anticancer drugs using xenotransplantation approaches. The ex utero development of zebrafish, optically transparent tissues in the first month of growth, and the immature adaptive immune system during this period greatly facilitate the manipulation of embryos. For highly aggressive cancers where patient survival may be expected to be only a few months, a zebrafish xenograft assay may be the only appropriate method as it requires only four to seven days. Thousands of embryos can be implanted with biopsy tissue from a patient to produce zebrafish xenografts and to use them to screen a large number of drugs and compounds automatically to develop an effective treatment regimen for a specific patient. This review examines the advantages and disadvantages of the zebrafish model in oncology research. The main focus is on the use of zebrafish xenografts to study metastasis and to create avatars in personalized medicine.

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斑马鱼 Xenographs 在肿瘤学和个性化医疗中的应用
摘要 有骨鱼斑马鱼(Danio rerio)已成为生物医学癌症研究中重要的脊椎动物模式生物之一,主要用于利用异种移植方法开发抗癌药物。斑马鱼在子宫外发育,在生长的第一个月组织呈光学透明状,在此期间适应性免疫系统尚未成熟,这些都大大方便了对胚胎的操作。对于病人存活期可能只有几个月的高侵袭性癌症,斑马鱼异种移植试验可能是唯一合适的方法,因为它只需要四到七天。可以将数千个胚胎植入患者的活检组织,以产生斑马鱼异种移植,并利用它们自动筛选大量药物和化合物,为特定患者制定有效的治疗方案。本综述探讨了斑马鱼模型在肿瘤学研究中的优缺点。主要重点是利用斑马鱼异种移植研究转移和在个性化医疗中创建化身。
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来源期刊
Molecular Biology
Molecular Biology 生物-生化与分子生物学
CiteScore
1.30
自引率
8.30%
发文量
78
审稿时长
3 months
期刊介绍: Molecular Biology is an international peer reviewed journal that covers a wide scope of problems in molecular, cell and computational biology including genomics, proteomics, bioinformatics, molecular virology and immunology, molecular development biology, molecular evolution and related areals. Molecular Biology publishes reviews, experimental and theoretical works. Every year, the journal publishes special issues devoted to most rapidly developing branches of physical-chemical biology and to the most outstanding scientists.
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