Recent advances in TBHP-promoted heterocyclic ring construction via annulation/cyclization

Abstract

One of the most often utilized hydroperoxides in an array of oxidation strategies is tert-butyl hydroperoxide (^tBuOOH, TBHP). The key reasons for rising utility of TBHP are its low cost, environmental friendliness, high efficiency, and ability to replace hazardous or rare heavy metal oxidants. In this sexennial update, we concisely and critically discussed the applications of TBHP in heterocyclic ring formations starting from 2018 to date. Merits and demerits of its utility, scope of a synthetic organic transformation along with mechanistic logistics are the key features of this review.