Maximizing Success: An Overview of Optimizing the Ovarian Tissue Transplantation Site.

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-08-26 DOI:10.5935/1518-0557.20240027
Koray Görkem Saçıntı, Rowaida Sadat, Sinan Özkavukçu, Meltem Sonmezer, Murat Sönmezer
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Abstract

Ovarian tissue cryopreservation and transplantation (OTCT) has emerged in recent years as a potential method for reversing abnormal endocrine and reproductive functions, particularly in patients receiving gonadotoxic cancer treatments having longer survival rates. From its first rodent experiments to human trials, OTCT has evolved tremendously, opening new windows for further utilization. Since then, significant progress has been achieved in terms of techniques used for surgical removal of the tissue, optimal fragment size, freezing and thawing procedures, and appropriate surgical sites for the subsequent reimplementation of the graft. In addition, various approaches have been proposed to decrease the risk of ischemic injury, which is the leading cause of significant follicle loss during neo-angiogenesis. This review aims to discuss the pros and cons of ovarian and retroperitoneal transplantation sites, highlighting the justifications for the viability and efficacy of different transplantation sites as well as the potential advantages and drawbacks of retroperitoneal or preperitoneal area.

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最大化成功:卵巢组织移植部位优化概述。
卵巢组织冷冻保存和移植(OTCT)是近年来出现的一种逆转异常内分泌和生殖功能的潜在方法,尤其适用于接受性腺毒性癌症治疗、存活率较长的患者。从最初的啮齿动物实验到人体试验,OTCT 已经取得了巨大的发展,为进一步的利用打开了新的窗口。从那时起,在手术切除组织的技术、最佳片段大小、冷冻和解冻程序以及随后重新植入移植物的适当手术部位等方面都取得了重大进展。此外,还提出了各种方法来降低缺血性损伤的风险,而缺血性损伤是新血管生成过程中卵泡大量丢失的主要原因。本综述旨在讨论卵巢和腹膜后移植部位的利弊,强调不同移植部位的可行性和有效性,以及腹膜后或腹膜前区域的潜在优势和缺点。
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来源期刊
CiteScore
3.30
自引率
6.70%
发文量
56
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