Time-series variation in the locomotor behavior and vocal traits of Japanese medaka (Oryzias latipes) acutely exposed to organophosphorus pesticide chlorpyrifos

IF 3.9 3区 环境科学与生态学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Comparative Biochemistry and Physiology C-toxicology & Pharmacology Pub Date : 2024-06-03 DOI:10.1016/j.cbpc.2024.109954
Mengcheng Zhuo , Xi Wang , Yanhong Shi , Kun Chen , Xuchun Qiu
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Abstract

Organophosphorus pesticides (OPs), such as chlorpyrifos (CPF), are the most commonly used pesticides worldwide. Considering that OPs will eventually enter aquatic ecosystems due to runoff from agricultural lands, accidental leakage, and other unforeseen emergencies, monitoring water pollution of those substances is crucial for environmental protection and public health. In this study, Japanese medaka (Oryzias latipes) were exposed to CPF (0.03, 0.06, and 0.12 mg/L) for 6 h, and the time-series variations in their locomotor behavior and vocal traits were investigated. Compared with that measured before exposure, significantly changed locomotor behavior and vocal traits in Japanese medaka exposed to CPF could be observed at 4 h after exposure and thereafter, and the pattern of behavioral changes depends on the CPF concentrations. Exposure to CPF also changed the frequency-sound pressure level curve of Japanese medaka at 6 h after exposure, especially at 0.12 mg/L. Moreover, CPF exposure could significantly inhibit the acetylcholinesterase (AChE) activity in the brains and eyes of medaka, which exhibited significant correlations with the variation of locomotor behavioral and vocal traits. Considering that inhibiting the AChE activity is the primary mechanism underlying the neurobehavioral toxicity of all OPs, our finding suggested that simultaneously monitoring changes in the locomotor behavioral and vocal traits has a high potential to reflect the pollution of organophosphorus substances.

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急性暴露于有机磷农药毒死蜱的日本青鳉运动行为和发声特征的时序变化
有机磷农药(OPs),如毒死蜱(CPF),是全球最常用的农药。考虑到有机磷农药最终会因农田径流、意外泄漏和其他不可预见的紧急情况而进入水生生态系统,监测这些物质对水体的污染对环境保护和公众健康至关重要。本研究将日本青鳉(Oryzias latipes)暴露于氯化石蜡(0.03、0.06 和 0.12 mg/L)中 6 小时,研究了其运动行为和发声特征的时间序列变化。与暴露前相比,暴露于氯化石蜡的日本鳉鱼在暴露后4小时及其后的运动行为和发声特征发生了显著变化,行为变化的模式取决于氯化石蜡的浓度。暴露于氯化石蜡后 6 小时,日本鳉鱼的频率-声压级曲线也发生了变化,尤其是在 0.12 mg/L 浓度下。此外,暴露于氯化石蜡可显著抑制青鳉大脑和眼睛中乙酰胆碱酯酶(AChE)的活性,这与青鳉运动行为和发声特征的变化有显著相关性。考虑到抑制乙酰胆碱酯酶活性是所有 OPs 对神经行为产生毒性的主要机制,我们的研究结果表明,同时监测运动行为和发声性状的变化极有可能反映有机磷物质的污染情况。
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来源期刊
CiteScore
7.50
自引率
5.10%
发文量
206
审稿时长
30 days
期刊介绍: Part C: Toxicology and Pharmacology. This journal is concerned with chemical and drug action at different levels of organization, biotransformation of xenobiotics, mechanisms of toxicity, including reactive oxygen species and carcinogenesis, endocrine disruptors, natural products chemistry, and signal transduction with a molecular approach to these fields.
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