Causal effects of sedentary behaviours on the risk of migraine: A univariable and multivariable Mendelian randomization study

IF 3.5 2区医学 Q1 ANESTHESIOLOGY European Journal of Pain Pub Date : 2024-06-04 DOI:10.1002/ejp.2296

Peihong Li, Jiaxin Li, Haoyue Zhu, Dandan Sheng, Zheng Xiao, Weiping Liu, Bo Xiao, Luo Zhou

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Abstract

Background

Migraine is a common and burdensome neurological disorder. The causal relationship between sedentary behaviours (SBs) and migraine remains instinct. We aimed to evaluate the roles of SBs including watching TV, using computer and driving in the risk of migraine.

Methods

We conducted a univariable and multivariable Mendelian randomization (MR) study based on summary datasets of large genome-wide association studies. The inverse variance weighted method was utilized as the primary analytical tool. Cochran's Q, MR-Egger intercept test, MR pleiotropy residual sum and outlier and leave-one-out were conducted as sensitivity analysis. Additionally, we performed a meta-analysis to combine the causal estimates.

Results

In the discovery analysis, we identified causal associations between time spent watching TV and an increased risk of migraine (p = 0.015) and migraine without aura (MO) (p = 0.002). Such causalities with increasing risk of migraine (p = 0.005), and MO (p = 0.006) were further verified using summary datasets from another study in the replication analysis. There was no significant causal association found between time spent using computer, driving and migraine or its two subtypes. The meta-analysis and multivariable MR analysis also strongly supported the causal relationships between time spent watching TV and an increased risk of migraine (p = 0.0003 and p = 0.034), as well as MO (p < 0.0001 and p = 0.0004), respectively. These findings were robust under all sensitivity analysis.

Conclusions

Our study suggested that time spent watching TV may be causally associated with an increased risk of migraine, particularly MO. Large-scale and well-designed cohort studies may be warranted for further validation.

Significance Statement

This study represents the first attempt to investigate whether a causal relationship exists between SBs and migraine. Utilizing MR analysis helps mitigate reverse causation bias and confounding factors commonly encountered in observational cohorts, thereby enhancing the robustness of derived causal associations. Our MR analysis revealed that time spent watching TV may serve as a potential risk factor for migraine, particularly MO.

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久坐行为对偏头痛风险的因果效应：单变量和多变量孟德尔随机化研究。

背景：偏头痛是一种常见且负担沉重的神经系统疾病。久坐行为（SBs）与偏头痛之间的因果关系仍不明朗。我们旨在评估包括看电视、使用电脑和开车在内的久坐行为在偏头痛风险中的作用：我们基于大型全基因组关联研究的汇总数据集，开展了一项单变量和多变量孟德尔随机化（MR）研究。主要分析工具是反方差加权法。作为敏感性分析，我们进行了 Cochran's Q、MR-Egger 截距检验、MR 多向性残差总和以及离群和剔除。此外，我们还进行了荟萃分析，以合并因果关系估计值：在发现分析中，我们发现了看电视时间与偏头痛（p = 0.015）和无先兆偏头痛（MO）（p = 0.002）风险增加之间的因果关系。这种因果关系与偏头痛（p = 0.005）和无先兆偏头痛（p = 0.006）风险增加的关系，在复制分析中通过另一项研究的汇总数据集得到了进一步验证。使用电脑的时间、驾驶与偏头痛或其两种亚型之间没有发现明显的因果关系。荟萃分析和多变量 MR 分析也有力地支持了看电视时间与偏头痛风险增加之间的因果关系（p = 0.0003 和 p = 0.034），以及 MO（p 结论）：我们的研究表明，看电视的时间可能与偏头痛尤其是MO风险的增加有因果关系。可能需要进行大规模、设计良好的队列研究来进一步验证：本研究首次尝试调查 SB 与偏头痛之间是否存在因果关系。利用磁共振分析有助于减少观察性队列中常见的反向因果偏差和混杂因素，从而提高推导出的因果关系的稳健性。我们的磁共振分析表明，看电视的时间可能是偏头痛（尤其是MO）的潜在风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Pain 医学-临床神经学

CiteScore

7.50

自引率

5.60%

发文量

163

审稿时长

4-8 weeks

期刊介绍： European Journal of Pain (EJP) publishes clinical and basic science research papers relevant to all aspects of pain and its management, including specialties such as anaesthesia, dentistry, neurology and neurosurgery, orthopaedics, palliative care, pharmacology, physiology, psychiatry, psychology and rehabilitation; socio-economic aspects of pain are also covered. Regular sections in the journal are as follows: • Editorials and Commentaries • Position Papers and Guidelines • Reviews • Original Articles • Letters • Bookshelf The journal particularly welcomes clinical trials, which are published on an occasional basis. Research articles are published under the following subject headings: • Neurobiology • Neurology • Experimental Pharmacology • Clinical Pharmacology • Psychology • Behavioural Therapy • Epidemiology • Cancer Pain • Acute Pain • Clinical Trials.