PDGFR signalling implicated in anti-resorptive effects of sclerostin blockade

IF 29.4 1区 医学 Q1 RHEUMATOLOGY Nature Reviews Rheumatology Pub Date : 2024-06-05 DOI:10.1038/s41584-024-01133-5
Sarah Onuora
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引用次数: 0

Abstract

New research provides a potential explanation for why long-term sclerostin neutralization leads to continued bone mass gain, despite attenuation of its short-term effects on bone formation.
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PDGFR 信号与阻断硬骨蛋白的抗骨质吸收作用有关。
新的研究提供了一种可能的解释,说明为什么长期中和硬骨素会导致骨量持续增加,尽管其对骨形成的短期影响有所减弱。
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来源期刊
Nature Reviews Rheumatology
Nature Reviews Rheumatology 医学-风湿病学
CiteScore
29.90
自引率
0.90%
发文量
137
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Rheumatology is part of the Nature Reviews portfolio of journals. The journal scope covers the entire spectrum of rheumatology research. We ensure that our articles are accessible to the widest possible audience.
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