Correlation of Noninvasive Cardiac MRI Measures of Left Ventricular Myocardial Function and Invasive Pressure-Volume Parameters in a Porcine Ischemia-Reperfusion Model.

IF 3.8 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Radiology. Cardiothoracic imaging Pub Date : 2024-06-01 DOI:10.1148/ryct.230252
Tejas Deshmukh, Dinesh Selvakumar, Sujitha Thavapalachandran, Oliver Archer, Gemma A Figtree, Michael Feneley, Stuart M Grieve, Liza Thomas, Faraz Pathan, James J H Chong
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Abstract

Purpose To assess the correlation between noninvasive cardiac MRI-derived parameters with pressure-volume (PV) loop data and evaluate changes in left ventricular function after myocardial infarction (MI). Materials and Methods Sixteen adult female swine were induced with MI, with six swine used as controls and 10 receiving platelet-derived growth factor-AB (PDGF-AB). Load-independent measures of cardiac function, including slopes of end-systolic pressure-volume relationship (ESPVR) and preload recruitable stroke work (PRSW), were obtained on day 28 after MI. Cardiac MRI was performed on day 2 and day 28 after infarct. Global longitudinal strain (GLS) and global circumferential strain (GCS) were measured. Ventriculo-arterial coupling (VAC) was derived from PV loop and cardiac MRI data. Pearson correlation analysis was performed. Results GCS (r = 0.60, P = .01), left ventricular ejection fraction (LVEF) (r = 0.60, P = .01), and cardiac MRI-derived VAC (r = 0.61, P = .01) had a significant linear relationship with ESPVR. GCS (r = 0.75, P < .001) had the strongest significant linear relationship with PRSW, followed by LVEF (r = 0.67, P = .005) and cardiac MRI-derived VAC (r = 0.60, P = .01). GLS was not significantly correlated with ESPVR or PRSW. There was a linear correlation (r = 0.82, P < .001) between VAC derived from cardiac MRI and from PV loop data. GCS (-3.5% ± 2.3 vs 0.5% ± 1.4, P = .007) and cardiac MRI-derived VAC (-0.6 ± 0.6 vs 0.3 ± 0.3, P = .001) significantly improved in the animals treated with PDGF-AB 28 days after MI compared with controls. Conclusion Cardiac MRI-derived parameters of MI correlated with invasive PV measures, with GCS showing the strongest correlation. Cardiac MRI-derived measures also demonstrated utility in assessing therapeutic benefit using PDGF-AB. Keywords: Cardiac MRI, Myocardial Infarction, Pressure Volume Loop, Strain Imaging, Ventriculo-arterial Coupling Supplemental material is available for this article. © RSNA, 2024.

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猪缺血再灌注模型中左心室心肌功能的无创心脏磁共振成像测量与有创压力-容积参数的相关性
目的 评估无创心脏磁共振成像衍生参数与压力-容积(PV)环路数据之间的相关性,并评估心肌梗塞(MI)后左室功能的变化。材料和方法 用心肌梗塞诱导 16 头成年雌性猪,其中 6 头作为对照组,10 头接受血小板衍生生长因子-AB (PDGF-AB)。在心肌梗死后第 28 天测量与负荷无关的心脏功能,包括收缩末压-容积关系斜率(ESPVR)和前负荷可招募搏动功(PRSW)。心肌梗塞后第 2 天和第 28 天进行了心脏核磁共振成像。测量了整体纵向应变(GLS)和整体周向应变(GCS)。根据 PV 环路和心脏磁共振成像数据得出心室-动脉耦合(VAC)。进行了皮尔逊相关分析。结果 GCS(r = 0.60,P = 0.01)、左室射血分数(LVEF)(r = 0.60,P = 0.01)和心脏磁共振成像得出的 VAC(r = 0.61,P = 0.01)与 ESPVR 呈显著线性关系。GCS(r = 0.75,P < .001)与 PRSW 的线性关系最为显著,其次是 LVEF(r = 0.67,P = .005)和心脏 MRI 导出 VAC(r = 0.60,P = .01)。GLS 与 ESPVR 或 PRSW 无明显相关性。心脏磁共振成像得出的 VAC 与 PV 回路数据之间存在线性相关(r = 0.82,P < .001)。与对照组相比,心肌梗死 28 天后接受 PDGF-AB 治疗的动物的 GCS(-3.5% ± 2.3 vs 0.5% ± 1.4,P = .007)和心脏 MRI 导出的 VAC(-0.6 ± 0.6 vs 0.3 ± 0.3,P = .001)显著改善。结论 MI 的心脏 MRI 派生参数与有创 PV 测量值相关,其中 GCS 的相关性最强。心脏磁共振成像衍生参数还证明了使用 PDGF-AB 评估治疗效果的实用性。关键词心脏磁共振成像、心肌梗死、压力容积环、应变成像、心室-动脉耦合 本文有补充材料。© RSNA, 2024.
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