{"title":"Rational design, synthesis and biological evaluation of Isoxazole incorporated oxazol-4-yl-1-(pyridin-4-yl)-1H-pyrazole as anticancer agents","authors":"","doi":"10.1016/j.cdc.2024.101146","DOIUrl":null,"url":null,"abstract":"<div><p>We have developed a new library of isoxazole skeleton having oxazol-4-yl)-1-(pyridin-4-yl)-1H-pyrazole derivatives (<strong>9a-j</strong>). Further, the biological activity of newly derived compounds (<strong>9a-j</strong>) was examined against four types of human cancer cell lines like breast cancer (MCF-7), lung cancer (A549), prostate cancer (DU-145) and breast cancer (MDA-MB-231) by employing of MTT assay, and etoposide used as reference drug candidate. The results were expressed with IC<sub>50</sub> µM. Most of the tested compounds displayed good to moderate activities on all cell lines. Among them, five derivatives <strong>9a, 9b, 9c, 9d</strong> and <strong>9e</strong> were possessed more potent activity. Principally, one of the compound <strong>9b</strong> showed remarkable activity.</p></div>","PeriodicalId":269,"journal":{"name":"Chemical Data Collections","volume":"52 ","pages":"Article 101146"},"PeriodicalIF":2.2180,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Data Collections","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S240583002400034X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Chemistry","Score":null,"Total":0}
引用次数: 0
Abstract
We have developed a new library of isoxazole skeleton having oxazol-4-yl)-1-(pyridin-4-yl)-1H-pyrazole derivatives (9a-j). Further, the biological activity of newly derived compounds (9a-j) was examined against four types of human cancer cell lines like breast cancer (MCF-7), lung cancer (A549), prostate cancer (DU-145) and breast cancer (MDA-MB-231) by employing of MTT assay, and etoposide used as reference drug candidate. The results were expressed with IC50 µM. Most of the tested compounds displayed good to moderate activities on all cell lines. Among them, five derivatives 9a, 9b, 9c, 9d and 9e were possessed more potent activity. Principally, one of the compound 9b showed remarkable activity.
期刊介绍：
Chemical Data Collections (CDC) provides a publication outlet for the increasing need to make research material and data easy to share and re-use. Publication of research data with CDC will allow scientists to: -Make their data easy to find and access -Benefit from the fast publication process -Contribute to proper data citation and attribution -Publish their intermediate and null/negative results -Receive recognition for the work that does not fit traditional article format. The research data will be published as ''data articles'' that support fast and easy submission and quick peer-review processes. Data articles introduced by CDC are short self-contained publications about research materials and data. They must provide the scientific context of the described work and contain the following elements: a title, list of authors (plus affiliations), abstract, keywords, graphical abstract, metadata table, main text and at least three references. The journal welcomes submissions focusing on (but not limited to) the following categories of research output: spectral data, syntheses, crystallographic data, computational simulations, molecular dynamics and models, physicochemical data, etc.
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