Emergence of lineage III of Shigella sonnei ST152 belonging to a high-risk clone harboring the blaCTX-M-15 gene in Peru

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-07-01 DOI:10.1016/j.ram.2024.02.007

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Abstract

Multidrug-resistant Shigella sonnei ST152, global lineage III, is a high-risk clone, whose dissemination has limited therapeutic options for shigellosis. This study aimed to characterize two isolates of S. sonnei, which were recovered in Lima, Peru, during November 2019, exhibiting resistance to extended-spectrum cephalosporins and quinolones, and concurrently harboring bla_CTX-M-15 and qnrS1 genes, in addition to mutations in gyrA-S83L. These isolates were resistant to ceftriaxone, ciprofloxacin and trimethoprim/sulfamethoxazole. The molecular analysis showed that both isolates belonged to lineage III, sublineages IIIa and IIIb. The bla_CTX-M-15 gene was located in the same genetic platform as qnrS1, flanked upstream by ISKpn19, on a conjugative plasmid belonging to the IncI-γ group. To the best of our knowledge, this would be the first report on S. sonnei isolates carrying the bla_CTX-M-15 gene in Peru. The global dissemination of S. sonnei ST152, co-resistant to β-lactams and quinolones, could lead to a worrisome scenario in the event of potential acquisition of genetic resistance mechanisms to azithromycin.

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秘鲁出现了属于携带 blaCTX-M-15 基因的高风险克隆的子代志贺氏菌 ST152 第三系。

具有多重耐药性的宋内志贺菌 ST152（全球Ⅲ系）是一种高风险克隆，其传播限制了志贺菌病的治疗方案。本研究旨在描述2019年11月在秘鲁利马发现的两株子代志贺氏菌分离株的特征，这两株分离株表现出对广谱头孢菌素和喹诺酮类药物的耐药性，同时携带blaCTX-M-15和qnrS1基因，此外gyrA-S83L也发生了突变。这些分离物对头孢曲松、环丙沙星和三甲双胍/磺胺甲噁唑具有抗药性。分子分析表明，这两个分离株属于 III 系，IIIa 和 IIIb 亚系。blaCTX-M-15 基因与 qnrS1 位于同一基因平台，其上游侧翼为 ISKpn19，位于属于 IncI-γ 组的共轭质粒上。据我们所知，这是秘鲁首次报道携带 blaCTX-M-15 基因的 S. sonnei 分离物。对β-内酰胺类药物和喹诺酮类药物共同耐药的S. sonnei ST152在全球范围内的传播，可能会导致对阿奇霉素产生基因耐药机制，从而引发令人担忧的局面。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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