[Research progress on the role of endothelial mechanically sensitive ion channel protein Piezo1 in diseases].

Xiaoting Zhang, Jinhai Liu, Xiaoming Deng, Lulong Bo
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引用次数: 0

Abstract

Endothelial cells have important physiological functions and regulatory effects related to the occurrence and development of various diseases. Piezo1 is a mechanically sensitive ion channel protein, which is widely distributed in various tissues of the body and participates in the occurrence and development of various diseases. Piezo1 is highly expressed in endothelial cells and plays an important regulatory role in endothelial cell function. This article reviews the structure and function of Piezo1, the physiological function and pathological damage mechanism of endothelial cells, and the role of endothelial cell Piezo1 in various diseases, in order to understand the function and regulation mechanism of endothelial cell Piezo1, and provide new targets and strategies for the treatment of related diseases.

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[内皮机械敏感离子通道蛋白 Piezo1 在疾病中作用的研究进展]。
内皮细胞具有重要的生理功能和调节作用,与各种疾病的发生和发展有关。Piezo1 是一种机械敏感性离子通道蛋白,广泛分布于人体的各种组织中,参与各种疾病的发生和发展。Piezo1 在内皮细胞中高表达,在内皮细胞功能中起着重要的调节作用。本文综述了Piezo1的结构和功能、内皮细胞的生理功能和病理损伤机制,以及内皮细胞Piezo1在各种疾病中的作用,以期了解内皮细胞Piezo1的功能和调控机制,为相关疾病的治疗提供新的靶点和策略。
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来源期刊
Zhonghua wei zhong bing ji jiu yi xue
Zhonghua wei zhong bing ji jiu yi xue Medicine-Critical Care and Intensive Care Medicine
CiteScore
1.00
自引率
0.00%
发文量
42
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