{"title":"Fly into tranquility: GABA’s role in Drosophila sleep","authors":"Ratna Chaturvedi, Patrick Emery","doi":"10.1016/j.cois.2024.101219","DOIUrl":null,"url":null,"abstract":"<div><p>Sleep is conserved across the animal kingdom, and <em>Drosophila melanogaster</em> is a prime model to understand its intricate circadian and homeostatic control. GABA (gamma-aminobutyric acid), the brain’s main inhibitory neurotransmitter, plays a central role in sleep. This review delves into GABA’s complex mechanisms of actions within <em>Drosophila’s</em> sleep-regulating neural networks. We discuss how GABA promotes sleep, both by inhibiting circadian arousal neurons and by being a key neurotransmitter in sleep homeostatic circuits. GABA’s impact on sleep is modulated by glia through astrocytic GABA recapture and metabolism. Interestingly, GABA can be coexpressed with other neurotransmitters in sleep-regulating neurons, which likely contributes to context-based sleep plasticity.</p></div>","PeriodicalId":11038,"journal":{"name":"Current opinion in insect science","volume":"64 ","pages":"Article 101219"},"PeriodicalIF":5.8000,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in insect science","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214574524000610","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Sleep is conserved across the animal kingdom, and Drosophila melanogaster is a prime model to understand its intricate circadian and homeostatic control. GABA (gamma-aminobutyric acid), the brain’s main inhibitory neurotransmitter, plays a central role in sleep. This review delves into GABA’s complex mechanisms of actions within Drosophila’s sleep-regulating neural networks. We discuss how GABA promotes sleep, both by inhibiting circadian arousal neurons and by being a key neurotransmitter in sleep homeostatic circuits. GABA’s impact on sleep is modulated by glia through astrocytic GABA recapture and metabolism. Interestingly, GABA can be coexpressed with other neurotransmitters in sleep-regulating neurons, which likely contributes to context-based sleep plasticity.
期刊介绍：
Current Opinion in Insect Science is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up–to–date with the expanding volume of information published in the field of Insect Science. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year.
The following 11 areas are covered by Current Opinion in Insect Science.
-Ecology
-Insect genomics
-Global Change Biology
-Molecular Physiology (Including Immunity)
-Pests and Resistance
-Parasites, Parasitoids and Biological Control
-Behavioural Ecology
-Development and Regulation
-Social Insects
-Neuroscience
-Vectors and Medical and Veterinary Entomology
There is also a section that changes every year to reflect hot topics in the field.
Section Editors, who are major authorities in their area, are appointed by the Editors of the journal. They divide their section into a number of topics, ensuring that the field is comprehensively covered and that all issues of current importance are emphasized. Section Editors commission articles from leading scientists on each topic that they have selected and the commissioned authors write short review articles in which they present recent developments in their subject, emphasizing the aspects that, in their opinion, are most important. In addition, they provide short annotations to the papers that they consider to be most interesting from all those published in their topic over the previous year.
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