Solmaz Yazdani , Anikó Lovik , Christina Seitz , Caroline Ingre , Fang Fang , John Andersson
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引用次数: 0
Abstract
Inflammation is a hallmark of amyotrophic lateral sclerosis (ALS) and is often assessed through biological samples. Due to the easier access, peripheral blood is more commonly phenotyped instead of cerebrospinal fluid (CSF) or affected tissues in ALS. Here, using flow cytometry, we compared the composition of T cell subsets in blood and CSF in ALS patients. We found consistent but weak correlations between blood and CSF for all T cell subsets examined. This finding implies that blood and CSF offer complementary information when characterizing T cell immunity in ALS and blood may not be used as a surrogate for CSF.
炎症是肌萎缩性脊髓侧索硬化症(ALS)的标志,通常通过生物样本进行评估。由于更容易获得,外周血而不是脑脊液(CSF)或 ALS 患者的受累组织更常被进行表型分析。在这里,我们使用流式细胞术比较了 ALS 患者血液和 CSF 中 T 细胞亚群的组成。我们发现血液和脑脊液中的所有 T 细胞亚群之间存在一致但微弱的相关性。这一发现意味着,在描述 ALS 的 T 细胞免疫特征时,血液和 CSF 可提供互补信息,而血液不可用作 CSF 的替代物。
期刊介绍:
Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.