Macrophages in tissue repair and regeneration: insights from zebrafish.

IF 4 Q2 CELL & TISSUE ENGINEERING Cell Regeneration Pub Date : 2024-06-11 DOI:10.1186/s13619-024-00195-w
Changlong Zhao, Zhiyong Yang, Yunbo Li, Zilong Wen
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引用次数: 0

Abstract

Macrophages play crucial and versatile roles in regulating tissue repair and regeneration upon injury. However, due to their complex compositional heterogeneity and functional plasticity, deciphering the nature of different macrophage subpopulations and unraveling their dynamics and precise roles during the repair process have been challenging. With its distinct advantages, zebrafish (Danio rerio) has emerged as an invaluable model for studying macrophage development and functions, especially in tissue repair and regeneration, providing valuable insights into our understanding of macrophage biology in health and diseases. In this review, we present the current knowledge and challenges associated with the role of macrophages in tissue repair and regeneration, highlighting the significant contributions made by zebrafish studies. We discuss the unique advantages of the zebrafish model, including its genetic tools, imaging techniques, and regenerative capacities, which have greatly facilitated the investigation of macrophages in these processes. Additionally, we outline the potential of zebrafish research in addressing the remaining challenges and advancing our understanding of the intricate interplay between macrophages and tissue repair and regeneration.

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组织修复和再生中的巨噬细胞:斑马鱼的启示。
巨噬细胞在损伤后调节组织修复和再生的过程中发挥着多方面的关键作用。然而,由于巨噬细胞具有复杂的组成异质性和功能可塑性,破译不同巨噬细胞亚群的性质并揭示它们在修复过程中的动态变化和精确作用一直是一项挑战。斑马鱼(Danio rerio)具有独特的优势,已成为研究巨噬细胞发育和功能(尤其是在组织修复和再生中)的宝贵模型,为我们了解巨噬细胞在健康和疾病中的生物学特性提供了宝贵的见解。在这篇综述中,我们介绍了与巨噬细胞在组织修复和再生中的作用相关的现有知识和挑战,并强调了斑马鱼研究的重大贡献。我们讨论了斑马鱼模型的独特优势,包括其遗传工具、成像技术和再生能力,这些都极大地促进了对这些过程中巨噬细胞的研究。此外,我们还概述了斑马鱼研究在应对剩余挑战和促进我们对巨噬细胞与组织修复和再生之间错综复杂的相互作用的理解方面的潜力。
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来源期刊
Cell Regeneration
Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
5.80
自引率
0.00%
发文量
42
审稿时长
35 days
期刊介绍: Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine
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