Framingham Stroke Risk Profile Score and White Matter Disease Progression.

IF 1.1 4区医学 Q4 CLINICAL NEUROLOGY Neurologist Pub Date : 2024-09-01 DOI:10.1097/NRL.0000000000000567

Hossam Youssef, Mutlu Demirer, Erik H Middlebrooks, Bhrugun Anisetti, James F Meschia, Michelle P Lin

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引用次数: 0

Abstract

Objectives: To evaluate the relationship between Framingham Stroke Risk Profile (FSRP) score and rate of white matter hyperintensity (WMH) progression and cognition.

Methods: Consecutive patients enrolled in the Mayo Clinic Florida Familial Cerebrovascular Diseases Registry (2011-2020) with 2 brain-MRI scans at least 1 year apart were included. The primary outcome was annual change in WMH volume (cm 3 /year) stratified as fast versus slow (above vs. below median). Cognition was assessed using a Mini-Mental State Exam (MMSE, 0-30). FSRP score (0 to 8) was calculated by summing the presence of age 65 years or older, smoking, systolic blood pressure greater than 130 mmHg, diabetes, coronary disease, atrial fibrillation, left ventricular hypertrophy, and antihypertensive medication use. Linear and logistic regression analyses were performed to examine the association between FSRP and WMH progression, and cognition.

Results: In all, 207 patients were included, with a mean age of 60±16 y and 54.6% female. FSRP scores risk distribution was: 31.9% scored 0 to 1, 36.7% scored 2 to 3, and 31.4% scored ≥4. The baseline WMH volume was 9.6 cm 3 (IQR: 3.3-28.4 cm 3 ), and the annual rate of WMH progression was 0.9 cm3/year (IQR: 0.1 to 3.1 cm 3 /year). A higher FSRP score was associated with fast WMH progression (odds ratio, 1.45; 95% CI: 1.22-1.72; P<0.001) and a lower MMSE score (23.6 vs. 27.1; P<0.001). There was a dose-dependent relationship between higher FSRP score and fast WMH progression (odds ratios, 2.20, 4.64, 7.86, 8.03 for FSRP scores 1, 2, 3, and ≥4, respectively; trend P <0.001).

Conclusions: This study demonstrated an association between higher FSRP scores and accelerated WMH progression, as well as lower cognition.

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弗雷明汉卒中风险档案评分与白质疾病进展。

目的评估弗雷明汉卒中风险档案（FSRP）评分与白质高密度（WMH）进展率和认知能力之间的关系：方法：纳入梅奥诊所佛罗里达家族性脑血管疾病登记处（2011-2020年）的连续入组患者，这些患者均接受过2次脑部MRI扫描，扫描时间至少间隔1年。主要结果是WMH体积（cm3/年）的年度变化，分为快慢两组（高于中位数与低于中位数）。认知能力采用迷你精神状态检查（MMSE，0-30 分）进行评估。FSRP评分（0至8分）是将65岁或65岁以上、吸烟、收缩压大于130 mmHg、糖尿病、冠心病、心房颤动、左心室肥厚和服用降压药等因素相加计算得出的。对FSRP和WMH进展以及认知能力之间的关系进行了线性和逻辑回归分析：共纳入 207 名患者，平均年龄（60±16）岁，女性占 54.6%。FSRP评分的风险分布为31.9%为0至1分，36.7%为2至3分，31.4%为≥4分。基线WMH体积为9.6立方厘米（IQR：3.3-28.4立方厘米），WMH的年进展率为0.9立方厘米/年（IQR：0.1-3.1立方厘米/年）。FSRP评分越高，WMH进展越快（几率比1.45；95% CI：1.22-1.72；PC结论：FSRP评分越高，WMH进展越快：该研究表明，FSRP评分越高，WMH进展越快，认知能力越低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurologist 医学-临床神经学

CiteScore

1.90

自引率

0.00%

发文量

151

审稿时长

2 months

期刊介绍： The Neurologist publishes articles on topics of current interest to physicians treating patients with neurological diseases. The core of the journal is review articles focusing on clinically relevant issues. The journal also publishes case reports or case series which review the literature and put observations in perspective, as well as letters to the editor. Special features include the popular "10 Most Commonly Asked Questions" and the "Patient and Family Fact Sheet," a handy tear-out page that can be copied to hand out to patients and their caregivers.