Membrane Lipid Replacement for reconstituting mitochondrial function and moderating cancer-related fatigue, pain and other symptoms while counteracting the adverse effects of cancer cytotoxic therapy.

IF 4.2 3区 医学 Q2 ONCOLOGY Clinical & Experimental Metastasis Pub Date : 2024-06-01 Epub Date: 2024-06-16 DOI:10.1007/s10585-024-10290-6
Garth L Nicolson, Gonzalo Ferreira de Mattos
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Abstract

Cancer-related fatigue, pain, gastrointestinal and other symptoms are among the most familiar complaints in practically every type and stage of cancer, especially metastatic cancers. Such symptoms are also related to cancer oxidative stress and the damage instigated by cancer cytotoxic therapies to cellular membranes, especially mitochondrial membranes. Cancer cytotoxic therapies (chemotherapy and radiotherapy) often cause adverse symptoms and induce patients to terminate their anti-neoplastic regimens. Cancer-related fatigue, pain and other symptoms and the adverse effects of cancer cytotoxic therapies can be safely moderated with oral Membrane Lipid Replacement (MLR) glycerolphospholipids and mitochondrial cofactors, such as coenzyme Q10. MLR provides essential membrane lipids and precursors to maintain mitochondrial and other cellular membrane functions and reduces fatigue, pain, gastrointestinal, inflammation and other symptoms. In addition, patients with a variety of chronic symptoms benefit from MLR supplements, and MLR also has the ability to enhance the bioavailability of nutrients and slowly remove toxic, hydrophobic molecules from cells and tissues.

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膜脂替代物用于重建线粒体功能,缓解癌症相关的疲劳、疼痛和其他症状,同时抵消癌症细胞毒疗法的不良影响。
与癌症有关的疲劳、疼痛、胃肠道症状和其他症状是几乎所有类型和阶段的癌症,尤其是转移性癌症最常见的症状。这些症状也与癌症氧化应激和癌症细胞毒疗法对细胞膜(尤其是线粒体膜)造成的损害有关。癌症细胞毒疗法(化疗和放疗)经常会引起不良症状,导致患者终止抗肿瘤治疗。口服 "膜脂替代物"(MLR)甘油磷脂和线粒体辅因子(如辅酶 Q10)可以安全地缓解与癌症有关的疲劳、疼痛和其他症状以及癌症细胞毒疗法的不良反应。MLR 可提供维持线粒体和其他细胞膜功能所必需的膜脂和前体,减轻疲劳、疼痛、胃肠道、炎症和其他症状。此外,各种慢性症状患者都能从 MLR 补充剂中获益,MLR 还能提高营养物质的生物利用率,缓慢清除细胞和组织中的有毒疏水分子。
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来源期刊
CiteScore
7.80
自引率
5.00%
发文量
55
审稿时长
12 months
期刊介绍: The Journal''s scope encompasses all aspects of metastasis research, whether laboratory-based, experimental or clinical and therapeutic. It covers such areas as molecular biology, pharmacology, tumor biology, and clinical cancer treatment (with all its subdivisions of surgery, chemotherapy and radio-therapy as well as pathology and epidemiology) insofar as these disciplines are concerned with the Journal''s core subject of metastasis formation, prevention and treatment.
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