Translocator protein (18 kDa) positron emission tomography imaging as a biomarker of neuroinflammation in epilepsy.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY Neurological Sciences Pub Date : 2024-11-01 Epub Date: 2024-06-16 DOI:10.1007/s10072-024-07648-9

Li Qin, Ling Xiao, Haoyue Zhu, Yangsa Du, Yongxiang Tang, Li Feng

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Abstract

Increasing evidence indicate that neuroinflammation triggered by glial cells plays a significant role in epileptogenesis. To this effect, the overexpression of translocator protein 18 kDa (TSPO) in activated microglia and astrocytes has been identified as an inflammatory biomarker in epilepsy. It is now possible to quantify neuroinflammation using non-invasive positron emission tomography (PET) imaging of TSPO. With the advancement of radiotracers, TSPO PET has become an innovative tool in elucidating the "neuroinflammatory machinery" of drug-resistant epilepsy. Furthermore, TSPO PET has demonstrated potential in detecting MRI-negative epileptogenic zones (EZ) and provided an innovative perspective in epileptic medical treatment. This manuscript presents a comprehensive exploration of the neuroinflammatory mechanisms of epilepsy, alongside a thorough review of TSPO PET studies conducted in clinical and preclinical settings. The primary objective is to deepen our understanding of epilepsy progression and to establish TSPO PET as an effective monitoring tool for treatment efficacy.

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转运蛋白（18 kDa）正电子发射断层成像作为癫痫患者神经炎症的生物标记物。

越来越多的证据表明，神经胶质细胞引发的神经炎症在癫痫发生中起着重要作用。为此，活化的小胶质细胞和星形胶质细胞中转运蛋白 18 kDa (TSPO) 的过度表达已被确定为癫痫的炎症生物标志物。现在可以利用 TSPO 的无创正电子发射断层扫描（PET）成像来量化神经炎症。随着放射性同位素的进步，TSPO PET 已成为阐明耐药性癫痫的 "神经炎症机制 "的创新工具。此外，TSPO PET 在检测磁共振成像阴性致痫区（EZ）方面已显示出潜力，并为癫痫医疗提供了创新视角。本手稿全面探讨了癫痫的神经炎症机制，并对在临床和临床前环境中进行的 TSPO PET 研究进行了深入回顾。其主要目的是加深我们对癫痫进展的理解，并将 TSPO PET 确立为一种有效的疗效监测工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.