Impact of surrounding tissue-type and peri-electrode gap in stereoelectroencephalography guided (SEEG) radiofrequency thermocoagulation (RF-TC): a computational study.

IF 3 3区 医学 Q2 ONCOLOGY International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-06-16 DOI:10.1080/02656736.2024.2364721
Santiago Collavini, Juan J Pérez, Enrique Berjano, Mariano Fernández-Corazza, Silvia Oddo, Ramiro M Irastorza
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Abstract

Purpose: To use computational modeling to provide a complete and logical description of the electrical and thermal behavior during stereoelectroencephalography-guided (SEEG) radiofrequency thermo-coagulation (RF-TC).

Methods: A coupled electrical-thermal model was used to obtain the temperature distributions in the tissue during RF-TC. The computer model was first validated by an ex vivo model based on liver fragments and later used to study the impact of three different factors on the coagulation zone size: 1) the difference in the tissue surrounding the electrode (gray/white matter), 2) the presence of a peri-electrode gap occupied by cerebrospinal fluid (CSF), and 3) the energy setting used (power-duration).

Results: The model built for the experimental validation was able to predict both the evolution of impedance and the short diameter of the coagulation zone (error < 0.01 mm) reasonably well but overestimated the long diameter by 2 - 3 mm. After adapting the model to clinical conditions, the simulation showed that: 1) Impedance roll-off limited the coagulation size but involved overheating (around 100 °C); 2) The type of tissue around the contacts (gray vs. white matter) had a moderate impact on the coagulation size (maximum difference 0.84 mm), and 3) the peri-electrode gap considerably altered the temperature distributions, avoided overheating, although the diameter of the coagulation zone was not very different from the no-gap case (<0.2 mm).

Conclusions: This study showed that computer modeling, especially subject- and scenario-specific modeling, can be used to estimate in advance the electrical and thermal performance of the RF-TC in brain tissue.

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立体脑电图引导(SEEG)射频热凝(RF-TC)中周围组织类型和电极周围间隙的影响:一项计算研究。
目的:利用计算模型对立体脑电图引导(SEEG)射频热凝(RF-TC)过程中的电热行为进行完整、合理的描述:方法:使用电热耦合模型获取射频热凝过程中组织内的温度分布。该计算机模型首先通过基于肝脏碎片的体外模型进行验证,随后用于研究三种不同因素对凝固区大小的影响:1)电极周围组织的差异(灰质/白质);2)是否存在被脑脊液(CSF)占据的电极周围间隙;3)使用的能量设置(功率-持续时间):结果:为实验验证而建立的模型能较好地预测阻抗的变化和凝血区的短直径(误差小于 0.01 毫米),但高估了长直径 2 - 3 毫米。根据临床条件调整模型后,模拟结果表明1)阻抗滚降限制了凝固的大小,但涉及过热(约 100 °C);2)触点周围的组织类型(灰质与白质)对凝固的大小有一定影响(最大差异为 0.84 mm);3)电极周围的间隙大大改变了温度分布,避免了过热,尽管凝固区的直径与无间隙的情况差别不大(结论:这项研究表明,计算机建模,尤其是针对特定对象和场景的建模,可用于提前估算脑组织中射频热转导的电热性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.90
自引率
12.90%
发文量
153
审稿时长
6-12 weeks
期刊介绍: The International Journal of Hyperthermia
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